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Moumoujus

PENTHORUM CHINENSE EXTRACT.

Valuable / HUMECTANT, SKIN CONDITIONING, SKIN PROTECTING

Penthorum Chinense Extract is a versatile botanical ingredient renowned for its comprehensive skin benefits. It effectively combats oxidative stress and inflammation, while also promoting collagen synthesis and addressing hyperpigmentation for enhanced skin health and appearance.

Summary

Antioxidant Soothing Moisturizer/Humectant Skin protecting Skin conditioning Anti-aging Brightening Anti-inflammatory Cellular Regeneration

Science

Mechanism of Action

This extract operates at a cellular level, demonstrating potent antioxidant capabilities by protecting skin cells (keratinocytes) from damage induced by UVB radiation and H2O2-mediated oxidative stress. It exerts anti-inflammatory action by downregulating key mediators such as cyclooxygenase-2 (COX-2) and interleukin-6 (IL-6). Furthermore, it possesses anti-photoaging effects through increasing type 1 procollagen gene expression and inhibiting matrix metalloproteinases (MMPs) and hyaluronidase, thereby supporting collagen and hyaluronic acid integrity. Its anti-melanogenic activity reduces melanin production, tyrosinase expression, and microphthalmia-associated transcription factor (MITF) protein levels. Additionally, it exhibits autophagy-inducing properties, contributing to cellular waste removal and regeneration.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In vitro studies using human keratinocytes (HaCaT cells) demonstrated that Penthorum chinense Pursh ethanol extract (Pc-EE) protected against cell death induced by UVB irradiation or H2O2-induced oxidative stress. It also enhanced type 1 procollagen gene (Col1A1) promoter activity and decreased the expression of MMPs, COX-2, IL-6, and hyaluronidase under oxidative stress conditions.
  2. 02 In melanocyte cells (B16F10), Pc-EE significantly reduced melanin production, decreased tyrosinase expression, and lowered microphthalmia-associated transcription factor (MITF) protein levels. These studies also indicated its capacity to induce autophagy.

Transparency

Dusting Analysis

Not commonly dusted

No specific data suggests this ingredient is commonly 'dusted' at sub-efficacious percentages in formulations. Its diverse mechanistic actions imply that meaningful inclusion would leverage its multi-functional benefits.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Low-temperature aqueous extraction methods have been shown to enhance flavor and preserve in vitro antioxidant activity in some extracts, indicating that processing temperature can influence its stability and properties.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Penthorum chinense has been historically reported as a non-toxic herbal medicine, showing no apparent toxicity or side effects in animals or humans when used for treating liver conditions. In vitro studies on HSC-T6 cells indicated minimal toxic effects below 80 μg/mL. While extensive dermal safety data is still pending a formal CIR review, current data suggests a low sensitization risk.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Penthorum Chinense Extract is a valuable botanical ingredient offering a broad spectrum of benefits, including potent antioxidant, anti-inflammatory, anti-aging, and brightening effects, with promising cellular renewal capabilities.

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References

Sources