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PENTASODIUM TETRACARBOXYMETHYL DIPEPTIDE-51.

Valuable / SKIN CONDITIONING

Pentasodium Tetracarboxymethyl Dipeptide-51 is a precision peptide engineered to activate the skin's endogenous repair systems. It offers a dual-action solution for hyperpigmentation while concurrently enhancing skin regeneration, fortifying the barrier function, and improving overall skin elasticity and complexion.

Summary

Skin Conditioning Anti-hyperpigmentation Skin brightening Skin regeneration Skin barrier enhancement Anti-aging (wrinkle reduction, elasticity) Melanin regulation Redness reduction

Science

Mechanism of Action

This advanced peptide operates by signaling the skin to initiate its natural repair and regeneration processes, thereby strengthening its structural integrity. As a key component of MelaTrepein™, it specifically addresses hyperpigmentation by stimulating autophagy to break down existing melanosomes within keratinocytes and inhibiting the uptake of new melanosomes. Additionally, related peptides such as PTPD-12 contribute to enhanced autophagy, which helps manage inflammation, regulate melanin production in both melanocytes and keratinocytes, and significantly improve skin barrier function.

Research

Clinical Evidence

High confidence
Effective range 0.01–2%
Optimal

2%

Key findings

  1. 01 Recommended for anti-hyperpigmentation and skin brightening, demonstrated to reduce melanosome uptake and PAR2 gene expression in keratinocytes when part of MelaTrepein™.
  2. 02 A closely related peptide, PTPD-12, showed significant improvements in skin barrier function (reduction in trans-epidermal water loss) and skin redness in sensitive skin after 4 weeks of application.
  3. 03 A cream containing PTPD-12 significantly reduced melanin levels in facial hyperpigmentation over 8 weeks, indicating its potential as a safe and effective therapeutic option for pigmentary disorders with no observed adverse effects.

Transparency

Dusting Analysis

Not commonly dusted

Based on the available data, there is no indication that this ingredient is commonly 'dusted' or included at ineffective concentrations purely for marketing claims.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

The ingredient, typically supplied as part of a complex like MelaTrepein™, is described as a transparent, slightly yellowish liquid, suggesting good stability under standard formulation conditions.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

While Pentasodium Tetracarboxymethyl Dipeptide-51 itself has not undergone direct CIR, SCCS, or FDA safety review, closely related peptides demonstrate an excellent safety profile. Pentasodium Tetracarboxymethyl Acetylhydroxyprolyl Dipeptide-12 is listed as 'SkinSAFE 100 Free' and 'Irritant Free'. Clinical studies on Pentasodium Tetracarboxymethyl Palmitoyl Dipeptide-12 (PTPD-12) consistently reported no significant adverse effects, good tolerability, and no skin irritation, collectively indicating a low sensitization risk for this peptide class.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Pentasodium Tetracarboxymethyl Dipeptide-51 is a valuable ingredient, leveraging advanced peptide technology to effectively address hyperpigmentation, improve skin barrier function, and promote overall skin rejuvenation.

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