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Moumoujus

PENTAPEPTIDE-6.

Valuable CAS - / SKIN CONDITIONING

A synthetic recombinant peptide, Pentapeptide-6 enhances epidermal-dermal communication by boosting stratifin protein production. This improved cellular signaling optimizes extracellular matrix turnover, promoting collagen and hyaluronic acid synthesis for dermal remodeling and wrinkle reduction.

Summary

Anti-aging Wrinkle Reduction Collagen Booster Hyaluronic Acid Production Skin Remodeling Firming

Science

Mechanism of Action

Pentapeptide-6, often presented as sh-Pentapeptide-6 Trifluoroacetate, functions as a biomessenger within the skin. It stimulates stratifin protein expression, which facilitates crucial communication between the epidermis and dermis. This optimized 'cross-talk' leads to enhanced extracellular matrix (ECM) turnover, balancing the degradation of aged collagen with the synthesis of new collagen types (I, III, Pro-collagen) and hyaluronic acid. Furthermore, it supports dermal reorganization, fortifying fibroblast strength and optimizing matrix contraction for improved skin architecture.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

1%

Key findings

  1. 01 Enhances epidermal stratifin expression, optimizing epidermal-dermal communication. Improves ECM turnover balance by promoting neo-collagen (Pro-collagen, Collagen I, Collagen III) and hyaluronic acid synthesis while aiding aged collagen degradation. Supports dermal reorganization, improving fibroblast strength and optimizing matrix contraction.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

For optimal stability and efficacy, products containing Pentapeptide-6 should ideally be housed in opaque, airless packaging. While generally compatible, it is advisable to avoid co-formulation or direct layering with highly acidic products (below pH 3.5) without careful consideration of routine separation.

Conflicts

  • Highly acidic products (below pH 3.5)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) Expert Panel has not specifically reviewed PENTAPEPTIDE-6 or sh-Pentapeptide-6 Trifluoroacetate. However, other pentapeptides, such as Myristoyl Pentapeptide-4, Palmitoyl Pentapeptide-4, and Pentapeptide-4, have been deemed safe for cosmetic use.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Pentapeptide-6 is a valuable peptide that actively improves epidermal-dermal communication and extracellular matrix health, leading to comprehensive dermal remodeling and visible wrinkle repair.

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