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Moumoujus

PENTAPEPTIDE-53.

Insufficient Data / SKIN CONDITIONING

Pentapeptide-53, identified by the sequence His-Gly-Asp-Gly-Ser, is a synthetic peptide designed to influence cellular lipid metabolism. It works to reduce the appearance of aging by actively decreasing fat cell formation and enhancing fat breakdown, resulting in a visibly smoother and more refined skin surface.

Summary

Anti-aging Skin rejuvenation Lipolysis promotion

Science

Mechanism of Action

This unique pentapeptide, with its His-Gly-Asp-Gly-Ser sequence, modulates adipogenesis within the skin by concurrently inhibiting lipogenesis (the synthesis of lipids) and promoting lipolysis (the breakdown of lipids). This dual action is believed to contribute to skin rejuvenation, aiding in the reduction of visible aging signs and fostering a smoother, more even complexion.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 7
0 7 14

Stability

For optimal preservation of bioactivity, Pentapeptide-53 should be stored short-term at 2-8°C and long-term at -20°C, consistently protected from both light and heat exposure. It is recommended to incorporate this ingredient into the aqueous phase of formulations during the cooling stage, specifically when temperatures are below 40°C.

Conflicts

  • high temperatures
  • oxidizing agents

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

Pentapeptide-53 is generally presented as safe, with assertions of being free from heavy metals and causing no skin or eye irritation. However, considering similar peptides from the same source have noted potential for mild irritation or allergic reactions in some individuals, a patch test is advisable. No official safety assessments by CIR, SCCS, or FDA specifically for Pentapeptide-53 have been identified.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Pentapeptide-53 demonstrates a promising mechanism for addressing visible signs of aging; however, further independent clinical validation and comprehensive safety assessments are required to definitively confirm its efficacy and suitability for all skin types.

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