Science
Mechanism of Action
As a signaling agent, PENTAPEPTIDE-5 is believed to prompt the skin's endogenous repair processes. Specifically, SH-Pentapeptide-5 is a single-chain human peptide synthesized to be identical to a segment of the leu-enkephalin protein. Related palmitoyl pentapeptides, such as the well-researched Palmitoyl pentapeptide-4, stimulate the production of crucial extracellular matrix proteins. These include collagen (specifically types I, III, and IV), elastin, fibronectin, and glycosaminoglycans, which are vital for replenishing and repairing the skin's structural components, leading to enhanced skin elasticity, firmness, and a reduction in wrinkles.
Research
Clinical Evidence
Medium confidence2.5%
Transparency
Dusting Analysis
No specific data suggests that PENTAPEPTIDE-5 is commonly included at ineffective or 'dusted' percentages in formulations.
The Formula
Formulation
Stability
Peptides are generally prone to physical and chemical degradation, making careful excipient compatibility and formulation stability crucial. For related peptides like Palmitoyl Pentapeptide-4, stable, low-pH bases are recommended to ensure optimal absorption and efficacy. Some cyclic pentapeptides show optimal stability around pH 3.0. Pentapeptide-59 is often formulated with emollient fatty acids (e.g., shea butter, lecithin) to aid delivery and stability. Solubility varies significantly among pentapeptides; palmitoyl-modified peptides tend to be oil-soluble, whereas unmodified peptides are often water-soluble.
Conflicts
- Excessive fragrance
- Alcohol
Safety
Safety Profile
PENTAPEPTIDE-5, under its exact nomenclature, has not been specifically reviewed by the Cosmetic Ingredient Review (CIR) Expert Panel, nor is it rated by Paula's Choice due to a lack of specific, readily available standalone safety data. The CIR Expert Panel is currently conducting a safety assessment for related peptides, including Myristoyl Pentapeptide-4, Palmitoyl Pentapeptide-4, and Pentapeptide-4, with a draft report released in August 2023.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While PENTAPEPTIDE-5 presents a promising mechanism of action and benefits observed in studies with related pentapeptides, a definitive assessment and robust clinical application require more specific, direct efficacy and safety data for PENTAPEPTIDE-5 itself.
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