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Moumoujus

PENTAPEPTIDE-35.

Insufficient Data / SKIN CONDITIONING

Pentapeptide-35, also known as Acetyl sh-Pentapeptide-35, is an advanced signaling peptide engineered to enhance cellular communication within the skin. It actively promotes repair and rejuvenation processes, working to improve skin firmness, lift, and overall condition.

Summary

Skin conditioning Cell-communicating ingredient Antioxidant Anti-inflammatory Collagen/Elastin preservation Firming Lifting

Science

Mechanism of Action

This sirtuin peptide modulates the cellular life cycle by interacting with human SIRT1 protein, facilitating deacetylation. This mechanism significantly reduces reactive oxygen species (ROS) production and increases NADPH levels, thereby decreasing cellular damage. Pentapeptide-35 also suppresses pro-inflammatory cytokines like Interleukin-8 (IL-8) and inhibits matrix metalloproteinases (MMPs), particularly MMP-9, which are critical for preserving the integrity of structural proteins such as collagen and elastin. Furthermore, it stimulates dermal fibroblasts and keratinocytes, bolstering natural protective mechanisms against free radicals and promoting the synthesis of extracellular matrix (ECM) components, including collagen and elastin.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

Due to the absence of specific clinical efficacy data, optimal concentration thresholds for effectiveness, or widely reported usage percentages, it is not possible to determine if this ingredient is commonly 'dusted' in formulations.

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

While specific optimal pH information for Acetyl sh-Pentapeptide-35 is not available, peptides generally benefit from stable, lower-pH bases for optimal absorption and efficacy. General peptide stability considerations apply.

Conflicts

  • Direct acids
  • Vitamin C
  • Retinoids
  • Strong antioxidants
  • Excessive fragrance
  • Alcohol

Safety

Safety Profile

CIR Status
Unknown
Sensitization risk Low

No specific safety assessment from CIR, SCCS, or FDA has been identified for PENTAPEPTIDE-35 or Acetyl sh-Pentapeptide-35. However, peptides in general are recognized for their excellent tolerability across all skin types, including sensitive skin, with an extremely low risk of allergic reactions.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Pentapeptide-35 demonstrates a promising, multi-faceted mechanism for cellular repair, rejuvenation, and protection, compatible with all skin types; however, specific clinical study data defining its efficacy at precise concentrations remains to be established.

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