Science
Mechanism of Action
This synthetic peptide, often found as Pentapeptide-34 Trifluoroacetate, functions by stimulating the Trans-prenyltransferase enzyme, which is crucial for increasing Coenzyme Q10 (CoQ10) levels within dermal cells. Elevated CoQ10, in turn, amplifies intracellular ATP production, leading to improved cellular vitality and enhanced protection against free radical-induced oxidative damage. It actively invigorates dermal cells, accelerating their renewal rate and combating the effects of glycation, a process contributing to skin aging.
Research
Clinical Evidence
Medium confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
It is typically formulated in water- and propanediol-based blends. However, Paula's Choice indicates potential aesthetic, stability, or other issues that could limit its overall utility in formulations.
Safety
Safety Profile
Pentapeptide-34 Trifluoroacetate is categorized as 'Unacceptable' by EWG due to its classification as a per- and polyfluoroalkyl substance (PFAS). PFAS chemicals are associated with severe health concerns, including potential links to cancer, allergies, immunotoxicity, developmental and reproductive toxicity, persistence and bioaccumulation in the body, organ system toxicity (specifically liver and cardiovascular systems), and endocrine disruption (acting as a thyroid disruptor).
Your Skin
Skin Compatibility
Our Assessment
Verdict
Despite its demonstrated efficacy in boosting CoQ10, offering antioxidant benefits, and improving skin firmness, Pentapeptide-34 is classified as a PFAS with severe health concerns and high irritancy, making it unsuitable for use in Moumoujus products.
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References
Sources