Science
Mechanism of Action
TETRAPEPTIDE-30 (PKEK) operates through a comprehensive pathway to mitigate hyperpigmentation. Its primary mechanism involves inhibiting tyrosinase activity, a crucial enzyme in melanin synthesis, and actively blocking the transfer of melanin to keratinocytes. Additionally, it deactivates melanocytes and exhibits anti-inflammatory properties by suppressing key inflammatory cytokines, which collectively reduces melanin production and fosters an even skin tone.
Research
Clinical Evidence
Medium confidence2.5%
Key findings
- 01 In vivo studies demonstrated a notable reduction in yellow skin tone from 4 weeks, faded age spots after 8 weeks, significant improvement in overall appearance within 2 weeks, and enhanced skin tone evenness by 4 weeks. Skin lesions also showed significant reduction within 4 weeks.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Peptides, including TETRAPEPTIDE-30, generally maintain optimal stability within a pH range of 5.0 to 7.0. For enhanced longevity, especially regarding deamidation, oxidation, and disulfide bridge protection, formulating in buffer solutions with a pH between 3.0 and 5.0 is recommended.
Safety
Safety Profile
TETRAPEPTIDE-30 is classified as non-comedogenic (0/5), making it well-suited for blemish-prone skin. Peptides generally present a low risk of irritation, reinforcing its suitability for various skin conditions.
Your Skin
Skin Compatibility
Our Assessment
Verdict
TETRAPEPTIDE-30, the functional equivalent for PENTAPEPTIDE-30 in available research, is a valuable peptide offering significant skin brightening, anti-aging, and soothing benefits with broad skin compatibility.
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