Science
Mechanism of Action
This peptide operates by actively reducing skin inflammation. It achieves this by markedly decreasing the expression and production of key pro-inflammatory cytokines, specifically IL-1α, IL-8, and TNF-α. Concurrently, it enhances the skin barrier's integrity by reducing Trans-Epidermal Water Loss (TEWL).
Research
Clinical Evidence
High confidence2%
Transparency
Dusting Analysis
Clinical efficacy for Pentapeptide-26 has been demonstrated at a 2% concentration, suggesting that lower, 'dusting' amounts may not provide comparable benefits. This indicates it is not an ingredient typically included at negligible concentrations purely for marketing claims.
The Formula
Formulation
Stability
Specific stability data for Pentapeptide-26 is not available. However, peptides generally are susceptible to degradation through processes such as deamidation, oxidation, hydrolysis, disulfide interchange, and racemization. For long-term stability, nonaqueous or substantially nonaqueous formulations may be necessary.
Safety
Safety Profile
No specific safety assessments from CIR, SCCS, or FDA were found for Capryloyl Pentapeptide-26. General safety assessments for other pentapeptides exist, but specific data for this ingredient is absent. Based on clinical studies with sensitive skin types and 'low' irritancy rating, the overall risk appears minimal.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Pentapeptide-26 is a valuable ingredient, clinically proven at 2% to soothe sensitive and irritated skin by significantly reducing redness, inflammation, and TEWL, making it highly beneficial for formulations targeting barrier integrity and comfort.
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References
Sources