Science
Mechanism of Action
Pentapeptide-2 (H-TYR-ILE-GLY-SER-ARG-NH2) functions primarily by stimulating the de novo synthesis of key extracellular matrix components, including collagen and elastin. This action directly supports the skin's structural scaffolding, improving its tensile strength and inherent elasticity. Functionally, this contributes to the maintenance of skin integrity, resistance to wrinkle formation, and an improvement in dermal thickness and hydration, resulting in a more plump and revitalized appearance.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Optimal stability in solution is achieved by buffering within a pH range of 5.0 to 6.0. Peptides are generally more stable in lyophilized form; for solutions, creating single-use aliquots and storing at -20°C or -80°C is advised to minimize degradation. General peptide considerations include potential hydrolysis in sequences containing aspartic acid, and moisture absorption leading to a gel-like consistency in peptides with lysine, arginine, or histidine.
Conflicts
- strong acids
- vitamin C (general peptide blend consideration)
- resveratrol (general peptide blend consideration)
- ferulic acid (general peptide blend consideration)
- salicylic acid (general peptide blend consideration)
Safety
Safety Profile
While the CIR Expert Panel has evaluated and deemed other pentapeptides (such as Myristoyl Pentapeptide-4, Palmitoyl Pentapeptide-4, and specific Pentapeptide-4 sequences like KTTKS and KTSKS) safe for cosmetic use, PENTAPEPTIDE-2 (H-TYR-ILE-GLY-SER-ARG-NH2) has not undergone a specific safety assessment by the CIR, SCCS, or FDA.
Your Skin
Skin Compatibility
Our Assessment
Verdict
PENTAPEPTIDE-2 offers a mechanistically sound approach to enhancing skin structure and elasticity, yet currently lacks specific clinical efficacy data and independent safety assessments.
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References
Sources