Science
Mechanism of Action
This peptide, and specifically its derivative Myristoyl Pentapeptide-16, functions by signaling skin cells to activate endogenous repair processes. This includes promoting collagen synthesis, strengthening the skin barrier, and improving moisture retention, which collectively supports skin health and may visibly reduce signs of aging.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 Myristoyl Pentapeptide-16, a derivative, promotes new hair growth of eyelashes and brows.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Peptides like Pentapeptide-16 are susceptible to degradation through processes such as deamidation, oxidation, and hydrolysis. Water can facilitate molecular unfolding and irreversible aggregation, suggesting that nonaqueous or substantially nonaqueous formulations may be necessary for optimal stability at ambient temperatures.
Conflicts
- High pH (can lead to aggregation and deamidation)
- Water (can lead to degradation and aggregation)
- Certain excipients (can cause aggregation, precipitation, or degradation)
Safety
Safety Profile
PENTAPEPTIDE-16 itself has not undergone specific safety assessments by CIR, SCCS, or FDA. However, the CIR has reviewed other pentapeptides, including Myristoyl Pentapeptide-4, Palmitoyl Pentapeptide-4, and Pentapeptide-4, concluding them safe under current use concentrations and practices.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Pentapeptide-16 offers valuable skin conditioning benefits, contributing to collagen synthesis and barrier function with a low risk of irritation, though direct clinical efficacy data for skin applications is limited.
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References
Sources