Science
Mechanism of Action
PENTAPEPTIDE-13 functions as an antagonist to alpha-Melanocyte-stimulating hormone (α-MSH) by binding to the melanocortin 1 receptor (MC1R) located on melanocytes. This interaction shifts melanin synthesis, favoring the production of phaeomelanin (lighter melanin) over eumelanin (darker melanin). The result is a reduction in hyperpigmentation and an improvement in skin luminosity, achieved through specific modulation rather than complete suppression of melanin synthesis.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The powder form of Pentapeptide-13 remains stable for 24 months when stored between -20°C and -15°C, requiring protection from light and air. For general peptide stability in formulations, buffered solutions within a pH range of 3-5 are often employed to mitigate deamidation and oxidation.
Conflicts
- Direct acids (e.g., AHAs, BHAs), retinoids, and potent antioxidants like Vitamin C are generally advised to be avoided when co-formulating with peptides, particularly in multi-peptide serums, to prevent potential degradation or compromised efficacy.
Safety
Safety Profile
PENTAPEPTIDE-13 has not been specifically reviewed by CIR, SCCS, or FDA. Peptides, constructed from natural amino acids, are broadly considered safe for topical use in skincare products. However, individual skin sensitivities can vary, making patch testing advisable, particularly for those with sensitive skin types.
Your Skin
Skin Compatibility
Our Assessment
Verdict
PENTAPEPTIDE-13 is a valuable peptide for targeted skin brightening and evening skin tone, leveraging a precise biomimetic mechanism to influence melanin production without inhibiting it.
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References
Sources