Science
Mechanism of Action
The primary mechanism of action for Peltophorum Dasyrhachis Bark Extract involves potent inhibition of tyrosinase, a key enzyme in the biosynthesis of melanin. Specific flavonoids isolated from its bark, such as (+)-2,3-trans-dihydrokaempferol and (+)-2,3-trans-dihydroquercetin, have demonstrated direct inhibition of L-DOPA oxidation, thereby reducing melanin formation and mitigating the appearance of dark spots. Broader research into related Peltophorum species and plant bark extracts also suggests potential antioxidant and anti-inflammatory activities, further supporting comprehensive skin health benefits.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Flavonoids isolated from Peltophorum dasyrachis bark, specifically (+)-2,3-trans-dihydrokaempferol (at 126 ± 3.2 µM) and (+)-2,3-trans-dihydroquercetin (at 210 ± 5.8 µM), exhibit potent tyrosinase inhibitory effects against L-DOPA oxidation.
- 02 Related studies on Peltophorum pterocarpum root bark extract demonstrate significant tyrosinase inhibition (81.89 ± 1.41% to 87.15 ± 0.07%) at an extract concentration of 500 µg/mL, suggesting broader utility within the Peltophorum genus for addressing hyperpigmentation.
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
Peltophorum Dasyrhachis Bark Extract is 'Not rated' by Paula's Choice, indicating a lack of comprehensive review or readily available safety data. There is no specific listing for this ingredient in CIR or SCCS reviews based on current searches.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Peltophorum Dasyrhachis Bark Extract demonstrates promising tyrosinase inhibitory effects through its isolated flavonoids, suggesting strong potential for hyperpigmentation management, although comprehensive safety and efficacy data for the full extract in topical applications are currently limited.
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