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Moumoujus

PELARGONIUM SIDOIDES ROOT EXTRACT.

Valuable CAS 1175005-95-4 / SKIN CONDITIONING

Pelargonium Sidoides Root Extract is a botanical active revered for its multifaceted biological activities. It delivers promising antimicrobial, anti-inflammatory, and immunomodulatory benefits, contributing to overall skin health. Traditionally recognized for addressing skin blemishes, it serves as a robust skin conditioning ingredient.

Summary

Skin Conditioning Antimicrobial Anti-inflammatory Antioxidant Immunomodulatory Barrier Support

Science

Mechanism of Action

This extract operates through several key pathways to promote skin health. It exhibits broad-spectrum antimicrobial efficacy, including antibacterial, antiviral, and antifungal properties, and can prevent microbial adhesion to host cells. Its anti-inflammatory action involves downregulating pro-inflammatory cytokines such as IL-6, TNF-α, IL-8, and PGE2, while also supporting a balanced immune response in the skin. Additionally, the extract possesses antioxidant potential due to its polyphenol content and aids in strengthening the epithelial barrier for enhanced tissue protection.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In vitro studies demonstrate that 60% and 11% root extracts, specifically at 100 mg/mL, significantly reduced IL-6 production, with the 60% extract showing a more pronounced effect.
  2. 02 In vitro analysis confirmed antibacterial and antifungal activity, with 60% extracts exhibiting Minimum Inhibitory Concentration (MIC) values ranging from 0.039 to 2.5 mg/mL against various pathogens.
  3. 03 Clinical studies primarily focus on oral administration for respiratory tract infections, with effective oral dosages ranging from 20 mg three times daily to 90 mg daily. Topical clinical efficacy data for human skin is currently limited.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

A precise optimal pH range for stability in topical cosmetic formulations has not been definitively identified. While some reports mention robustness against 'extreme pH conditions' for specific in vitro activities, this does not directly translate to general cosmetic formulation stability.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

There is no direct Cosmetic Ingredient Review (CIR) or Scientific Committee on Consumer Safety (SCCS) assessment available for the topical cosmetic use of Pelargonium Sidoides Root Extract. Oral consumption is generally well-tolerated, though mild gastrointestinal issues (e.g., diarrhea, nausea) and rare allergic reactions have been reported. Allergic reactions have also been noted in Germany with Pelargonium extract.

Your Skin

Skin Compatibility

Yes Normal
No Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Pelargonium Sidoides Root Extract is a valuable botanical offering promising antimicrobial, anti-inflammatory, and antioxidant benefits, particularly suited for blemish-prone and sensitive skin, although further topical clinical studies are required to establish optimal efficacy and concentrations.

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