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Moumoujus

PELARGONIUM SIDOIDES ADVENTITIOUS ROOT EXTRACT.

Valuable / ANTIMICROBIAL, ANTIOXIDANT, HUMECTANT, SKIN PROTECTING

This potent botanical extract offers multifaceted benefits for the skin, acting as a robust antioxidant, a balancing antimicrobial, and a protective humectant. It leverages a rich phytocomposition to enhance skin's natural defenses and overall health.

Summary

Antimicrobial Antioxidant Humectant Skin-Protecting

Science

Mechanism of Action

PELARGONIUM SIDOIDES ADVENTITIOUS ROOT EXTRACT is rich in beneficial phytocompounds, including coumarins and various polyphenols like proanthocyanidins, gallic acid, catechin, and taxifolin. For the skin, its action is primarily through bacterial-balancing and potent antioxidant effects, preventing oxidation and deterioration of other ingredients. It provides comprehensive antimicrobial (both antibacterial and antifungal) properties, which can be bacteriostatic or bactericidal, and also exhibits an antiadhesive effect, hindering bacterial attachment to human cells. Furthermore, it modulates the immune response by influencing gene expression, leading to increased cytokine production (IL-1, IL-2, IL-6, IL-10, TNF-α, and IFN) and boosting cellular defense mechanisms like phagocytosis. This extract also supports tissue integrity and strengthens the epithelial barrier function.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Clinical trials for an internal proprietary extract (EPs 7630) have demonstrated significant efficacy in treating acute respiratory tract infections. For instance, a 60 mg daily dose showed a 90.0% success rate in children with acute tonsillopharyngitis compared to 44.7% with placebo (p<0.001).
  2. 02 In adults with acute bronchitis, 30 drops three times daily of EPs 7630 for 7 days significantly reduced symptom severity and shortened the duration of working inability (p < 0.0001 for Bronchitis Severity Score decrease on day 7).
  3. 03 EPs 7630 was also found effective for the common cold, with 51% of patients showing 'major improvement' versus 12% with placebo. It is crucial to note that these studies pertain to internal consumption, and specific topical clinical efficacy data for skin applications is not provided.

Transparency

Dusting Analysis

Not commonly dusted

No specific data regarding common 'dusting' practices or thresholds for this ingredient in topical formulations is available within the provided research.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Aqueous extracts of Pelargonium sidoides demonstrate notable stability, retaining activity even after exposure to boiling, drying processes, and extreme pH conditions. Extracts are frequently prepared using ethanol (e.g., 11% or 60% w/w), confirming its compatibility with ethanolic solutions.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

A proprietary extract of Pelargonium sidoides (EPs 7630) has been extensively studied in clinical trials, predominantly for internal use, and is generally considered safe and well-tolerated. Reported adverse events are rare and typically mild, including gastrointestinal discomfort, mild bleeding, and allergic reactions (primarily for internal consumption). The European Medicines Agency (EMA) has approved EPs® 7630. Allergic skin reactions have been rarely noted, indicating a low risk for topical applications.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

PELARGONIUM SIDOIDES ADVENTITIOUS ROOT EXTRACT is a valuable ingredient, offering broad-spectrum antimicrobial, potent antioxidant, humectant, and skin-protecting benefits across all skin types, with a low risk of irritation and comedogenicity.

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