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Moumoujus

PEI-42.

Insufficient Data / DISPERSING NON-SURFACTANT

PEI-42, identified as Pullulan Acetate, is a sophisticated film-forming polymer derived from the natural saccharide, Pullulan. It is designed to create a thin, elastic film on the skin, offering immediate visible tightening and potentially enhancing the efficacy of co-formulated active ingredients.

Summary

skin conditioning skin protecting film-forming thickening

Science

Mechanism of Action

As a Pullulan Acetate derivative, PEI-42 functions primarily by forming a thin, resilient, and breathable film on the skin's surface. This polymeric matrix imparts a gentle tension upon drying, which contributes to an immediate, perceptible improvement in skin tautness. Beyond its tightening effect, the film acts as a protective barrier, reducing transepidermal water loss and potentially enhancing the penetration and absorption of other co-formulated active ingredients. Its structure also suggests utility as a biomaterial for encapsulating and delivering substances, indicating a controlled-release capability within sophisticated skincare formulations.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

No data available on dusting characteristics for PEI-42.

The Formula

Formulation

Solubility
Both
Optimal pH 2 – 11
0 7 14

Stability

The parent polymer, Pullulan, exhibits excellent stability across a broad pH range from 2.0 to 11.0. However, Pullulan Acetate, particularly in nanoparticle drug delivery systems, has demonstrated pH-sensitive release characteristics, with faster release at acidic pH 5 compared to neutral pH 7.4. This indicates that while the ingredient itself is robust, its interaction or release profile within a formulation may be pH-dependent.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Low

No specific Cosmetic Ingredient Review (CIR) or Scientific Committee on Consumer Safety (SCCS) reports were found for PEI-42 Pullulan Acetate, indicating insufficient safety data from these bodies. Paula's Choice notes it is unrated due to ongoing research. However, its parent compound, Pullulan, is generally recognized as safe (FDA GRAS notice) and is characterized as non-irritant, non-toxic, and skin-friendly. Studies involving Pullulan Acetate nanoparticles for drug delivery systems in mice demonstrated good tolerability at a dose of 200 mg/kg, suggesting a low sensitization risk for this derivative.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

PEI-42 offers promising film-forming, protective, and potential delivery system capabilities for skin, though specific clinical efficacy data for its direct cosmetic application and formal safety assessments are currently limited.

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