Science
Mechanism of Action
PEG-75 Lanolin acts on the skin by forming a thin, occlusive layer on the surface, which effectively minimizes trans-epidermal water loss and maintains optimal moisture levels, contributing to a smoother and softer epidermis. It functions as a humectant to actively draw and retain moisture, boosting hydration, and provides a lubricating effect on the skin's surface. In formulations, it is a key emulsifying agent, stabilizing oil-in-water systems, and a solubilizer capable of integrating hydrophobic substances into aqueous solutions. Its surfactant properties also offer mild cleansing and wetting benefits.
Research
Clinical Evidence
High confidence20%
Key findings
- 01 Clinical evaluations suggest PEG Lanolins, including PEG-75 Lanolin, are optimally utilized between 0.5% and 20%. Concentrations exceeding 20% have been associated with potential adverse skin reactions such as rashes, itching, and redness.
- 02 Broader cosmetic applications typically incorporate polyether lanolins within a concentration range of 0.001% to 15%.
- 03 Safety reviews for PEG Lanolins generally indicate mild to negligible skin irritation and no sensitization across animal and human studies, even at high concentrations (10-100%).
- 04 Specifically, 100% PEG-75 Lanolin demonstrated no adverse skin reactions in 11 subjects during a 4-week patch test period.
Transparency
Dusting Analysis
PEG-75 Lanolin is not typically 'dusted' in formulations; it is clinically recommended for use up to 20% and has shown safety at much higher concentrations in specific studies. However, exceeding 20% in general cosmetic applications may lead to adverse effects like rashes or irritation, establishing this as a cautionary threshold for formulation.
The Formula
Formulation
Stability
This ingredient maintains stability across a wide pH range of 2 to 10. Being nonionic, it exhibits compatibility with most other solubilizers and up to 10% electrolyte solutions. Its solution is minimally affected by both oxidative and reducing agents. While predominantly hydrophobic, it effectively solubilizes hydrophobic substances in aqueous systems. It is very soluble in water and in aqueous ethanol solutions up to 40%. Proper storage involves a cool, dry, well-ventilated environment, shielded from moisture, heat, and ignition sources.
Synergies
- Most other solubilizers
- Up to 10% electrolyte solutions
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has affirmed PEG Lanolins, including PEG-75 Lanolin, as safe for use in cosmetics and personal care products. However, some industry sources advise against its inclusion in formulations intended for children and pregnant individuals. While trace amounts of 1,4-dioxane, a by-product of the ethoxylation process, may be present, these can be effectively managed through purification methods. Allergic reactions are exceptionally rare and are primarily confined to individuals with known sensitivity to lanolin itself.
Your Skin
Skin Compatibility
Our Assessment
Verdict
PEG-75 Lanolin is a highly valuable, multifunctional ingredient that enhances skin hydration and texture while serving as an effective emulsifier and solubilizer in a broad range of stable cosmetic formulations.
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References
Sources