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Moumoujus

PEG-10.

Valuable CAS 25322-68-3 / HUMECTANT, SOLVENT

PEG-10 is a polyethylene glycol derivative primarily recognized for its humectant and solvent properties, aiding in skin hydration and the solubilization of other ingredients. Its common dimethicone derivative further acts as an effective emulsifier and skin conditioner, forming a protective film that reduces moisture loss and enhances product texture and spreadability.

Summary

Humectant Solvent Emulsifier Conditioner Delivery Enhancer

Science

Mechanism of Action

As a polyethylene glycol, PEG-10 functions to attract and draw moisture from the environment to the skin's surface, contributing to hydration, and serves as a solvent to effectively dissolve other components within a formulation. The derivative, PEG-10 Dimethicone, specifically forms a breathable, conditioning film on the skin. This film provides lubrication, protects the skin by reducing transepidermal water loss and blocking harmful external substances, and imparts a silky, non-greasy feel while enhancing product flow and application. It also acts as a vehicle to improve the delivery and penetration of other active ingredients.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Clinical observations indicate that PEG-based vehicles enhance the delivery and efficacy of therapeutic treatments, as evidenced by a case series demonstrating 75% efficacy with minimal irritation when employed in salicylic acid peels for comedogenic acne.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

PEG-10 Dimethicone exhibits stability in neutral, mildly acidic, and mildly alkaline aqueous solutions, though its integrity is compromised by strong acids or alkalis. It functions as a high HLB emulsifier, making it suitable for water-based and alcohol-based systems, and displays excellent compatibility with a wide range of surfactants and active ingredients. For water-in-oil emulsions, it should be initially incorporated into the silicone/oil phase, followed by gradual addition of the water phase. The inclusion of 1% Magnesium Sulfate is noted to improve the stability of water-in-oil formulations.

Synergies

  • Surfactants
  • Active ingredients
  • Magnesium Sulfate (for W/O emulsion stability)

Conflicts

  • Strong acids
  • Strong alkalis
  • Strong chemical combinations

Safety

Safety Profile

CIR Status
Safe as used
Max tested
10%
Sensitization risk Low

The Cosmetics Ingredient Review (CIR) panel considers PEG-10, including its dimethicone and propylene glycol derivatives, safe for use in cosmetic formulations at concentrations up to 10%. The CIR Panel notably removed a previous caveat concerning its use on damaged skin in 2010, affirming its general safety. Manufacturers are, however, advised to minimize potential impurities like 1,4-dioxane. The European Cosmetics Regulation (SCCS) also recognizes PEG-10 as safe for cosmetic applications, recommending adherence to specified usage guidelines and advising caution against its combination with other strong chemical compounds to minimize potential irritation.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

PEG-10 is a versatile ingredient, providing humectant and solvent properties, and in its dimethicone form, acts as an effective emulsifier and conditioner, enhancing active delivery and product aesthetics.

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