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Moumoujus

PASTINACA SATIVA ROOT EXTRACT.

Avoid CAS 90082-39-6 / HUMECTANT

Pastinaca Sativa Root Extract, derived from the parsnip root, possesses antioxidant, anti-inflammatory, antimicrobial, and humectant properties. However, its notable furanocoumarin content, including xanthotoxin, presents a significant risk of phototoxicity and skin irritation, largely precluding its safe use in topical formulations.

Summary

Antioxidant Anti-inflammatory Antimicrobial Humectant

Science

Mechanism of Action

This extract's pharmacological properties are attributed to active compounds such as furanocoumarins, flavonoids, and polyacetylenes. Coumarins have demonstrated anti-inflammatory activity by reducing inflammation markers in animal studies. Flavonoids and polyacetylenes contribute antioxidant and antimicrobial effects, while the extract itself acts as a humectant to enhance skin hydration. The furanocoumarin xanthotoxin, known for its photosensitizing properties, has historically been utilized in dermatological treatments for conditions like psoriasis and vitiligo.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Furanocoumarins, critical active components, are primarily lipophilic with limited water solubility, though water-soluble extracts have been developed. The overall extract's solubility can vary depending on extraction methodology. The paramount formulation concern is its inherent phototoxicity, which necessitates strict avoidance in products intended for sun exposure.

Conflicts

  • Direct sun exposure (due to phototoxicity)
  • Sensitive skin types (due to potential irritation)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

Pastinaca Sativa Root Extract carries a high risk of phototoxicity, predominantly due to its furanocoumarin content (e.g., xanthotoxin). Topical application followed by sun exposure can induce severe skin sensitization, manifesting as rashes and persistent blisters. Coumarins within the extract can also irritate sensitive skin. No specific CIR, SCCS, or FDA safety assessments, nor maximum safe concentrations for topical cosmetic use, have been established.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Given the significant risk of phototoxicity and high irritancy, particularly for sensitive skin, Pastinaca Sativa Root Extract is not recommended for topical cosmetic applications, especially in products that may be exposed to sunlight.

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