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Moumoujus

PASSIFLORA ALATA LEAF EXTRACT.

Valuable CAS - / SKIN CONDITIONING

A botanical extract derived from the leaves of Passiflora alata, this ingredient is recognized for its potent anti-inflammatory and antioxidant properties. It actively works to soothe skin irritation, reduce redness, and provide hydration, making it a versatile component in precision skincare formulations.

Summary

skin conditioning antioxidant anti-inflammatory moisturizer/humectant soothing

Science

Mechanism of Action

Passiflora alata leaf extract functions by significantly inhibiting the secretion of pro-inflammatory cytokines, specifically Interleukin-6 (IL-6) and Interleukin-8 (IL-8), within human fibroblasts. This action is attributed to its rich composition of flavonoids (such as chrysin and vitexin) and alkaloids. Furthermore, these flavonoids and phenolic acids confer robust antioxidant capabilities, neutralizing free radicals and mitigating oxidative stress. The extract also contributes to skin comfort through potential neuroprotective effects and supports barrier function by providing moisturizing and hydrating benefits.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Demonstrated an inhibition of IL-6 secretion by 15% (LPS stimulated) and 68% (LPS + LPS stimulated), and IL-8 secretion by 34% (LPS stimulated) and 24% (LPS + LPS stimulated) in human fibroblasts.
  2. 02 Showed substantial inhibition of IL-6 secretion (73% with LPS stimulation, 96% with LPS + LPS stimulation) and IL-8 secretion (85% with LPS stimulation, 78% with LPS + LPS stimulation) in human fibroblasts. A 'Sample A' with 16.54% total flavonoids achieved 91% inhibition of IL-6 and 90% inhibition of IL-8 (LPS stimulated), and 85% inhibition of IL-6 and 86% inhibition of IL-8 (UVB stimulated).
  3. 03 Exhibited significant anti-inflammatory activity, leading to 84% inhibition of IL-6 and 65% inhibition of IL-8 (LPS stimulated), and 80% inhibition of IL-6 and 57% inhibition of IL-8 (UVB stimulated) in human fibroblasts.

Transparency

Dusting Analysis

Not commonly dusted

Based on the robust in vitro efficacy demonstrated across various concentrations and stimuli, this ingredient is not typically considered a 'dusting' ingredient.

The Formula

Formulation

Solubility
Water
Optimal pH ≥5
0 7 14

Stability

An aqueous ethanol solution acidified to pH 5.0 was used during an extraction process, suggesting stability in this acidic range during processing.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

No direct CIR, SCCS, or FDA safety status has been established. In vitro cytotoxicity tests demonstrated excellent cell viability, maintaining 80% or more of control levels at concentrations up to 2.0 mg/ml. Phototoxicity tests indicated no phototoxic potential. While high oral/intraperitoneal doses in non-skin related in vivo studies showed some toxicological changes (e.g., reduced body mass), these are not relevant for topical cosmetic application, which generally exhibits low toxicity. COSMILE Europe recognizes its 'SKIN CONDITIONING' function.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Passiflora Alata Leaf Extract is a valuable botanical ingredient offering scientifically supported anti-inflammatory and antioxidant benefits, making it highly compatible for a broad spectrum of skin types, particularly sensitive and compromised skin.

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