Science
Mechanism of Action
Pantothenic Acid, or its derivative Panthenol, functions as a powerful humectant, efficiently attracting and retaining moisture within skin cells, thereby improving elasticity and smoothness. It actively supports rapid wound healing, stimulates collagen production, minimizes the appearance of fine lines, and fortifies the skin's protective barrier. This vitamin also exhibits anti-inflammatory properties, providing relief for irritated skin and potentially aiding in managing conditions such as acne, eczema, and rosacea, while also helping to regulate sebum. The Yeast Polypeptide component, while not extensively detailed for topical application in this specific combination, contributes general bioactivity such as superoxide anion scavenging.
Research
Clinical Evidence
High confidence3-5% (for panthenol, a derivative of pantothenic acid)
Key findings
- 01 Topical application of 3-5% panthenol has demonstrated improved skin moisture retention, particularly for dry or dull skin, alongside accelerated wound healing, reduced scarring, enhanced collagen synthesis, and a strengthened skin barrier.
- 02 Oral administration of pantothenic acid (2.2g/day) over 12 weeks reduced total facial acne lesions in healthy adults.
- 03 Higher oral doses of pantothenic acid (10g/day) were reported to manage moderate to severe acne over an 8-week period or longer.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Pantothenic acid is a stable, water-soluble vitamin, with calcium pantothenate often used for enhanced shelf-life. Yeast peptides demonstrate strong acid-base and thermal stability. To maintain ingredient integrity, formulations should minimize high moisture content, which can accelerate degradation, and avoid solvents incompatible with peptides.
Conflicts
- High moisture content in formulations can potentially lead to degradation of active ingredients.
- Solvents that react with or promote degradation of peptides should be avoided.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has confirmed the safety of Panthenol, Pantothenic Acid, and their derivatives in cosmetic applications at current usage levels. While a specific maximum topical concentration for 'Pantothenic Acid/Yeast Polypeptide' is not noted, oral intake of pantothenic acid is generally safe up to 1 gram/day, with higher doses potentially causing mild gastrointestinal upset.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This ingredient is valuable for its multifaceted benefits, including significant hydration, skin barrier reinforcement, and soothing properties, making it suitable for a wide range of skin types and concerns.
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