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PANTOLACTONE.

Valuable CAS 599-04-2; 79-50-5 / HUMECTANT, SKIN CONDITIONING

Pantolactone is a synthetic humectant crucial for maintaining optimal skin hydration, actively attracting and retaining moisture. It serves as a vital precursor for skin-beneficial B vitamins, contributing to a strengthened skin barrier and enhanced cellular regeneration. This versatile ingredient promotes smoother, more elastic skin while balancing hydration and reducing inflammation.

Moisturizer/Humectant Skin-Conditioning Agent Skin Barrier Support Anti-inflammatory Cell Regeneration Promoter Emulsion Stabilizer

Science

Pantolactone operates primarily as a humectant, effectively drawing and binding moisture within the skin's stratum corneum to preserve essential hydration levels. Beyond its direct moisturizing capabilities, it actively fortifies the skin barrier, a critical function for protecting against environmental stressors and minimizing transepidermal water loss. The ingredient stimulates cellular regeneration, leading to a refined skin texture characterized by improved smoothness and elasticity. Furthermore, Pantolactone demonstrates anti-inflammatory properties, aiding in the reduction of redness, which is particularly advantageous for sensitive skin. A key aspect of its efficacy is its role as a precursor in the body's synthesis of Panthenol (Pro-Vitamin B5) and Pantothenic Acid (Vitamin B5), both celebrated for their skin-conditioning, healing, and soothing effects. In formulation, it also functions as an emulsion stabilizer.


Research

High confidence
Effective range 0.5–1%
Optimal

1%


Transparency

Not commonly dusted

The Formula

Solubility
Water
Optimal pH 3.5 – 6.5
0 7 14

Stability

Pantolactone exhibits excellent stability and compatibility across a diverse range of cosmetic formulations. While it possesses good heat tolerance, it is advisable to maintain processing temperatures below 90°C to preserve its optimal integrity and performance.

Synergies

  • Ingredients that support skin's natural metabolic pathways, enhancing the conversion to Panthenol and Pantothenic Acid.
  • Other humectants for enhanced hydration.

Safety

CIR Status
Safe as used
Max tested
1%
Sensitization risk Low

The CIR Expert Panel has concluded that Pantolactone, as a derivative and impurity of Panthenol and Pantothenic Acid, is safe for use in cosmetics at current concentrations and practices, typically not exceeding 1%. Although generally well-tolerated, there have been infrequent reports of allergic contact dermatitis in individuals with heightened sensitivities.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Valuable

Pantolactone is a valuable humectant and skin conditioner that effectively enhances barrier function, supports cell regeneration, and acts as a B vitamin precursor, promoting balanced, resilient skin across all types with a low risk of irritation.


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