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Moumoujus

PANTOEA AGGLOMERANS FERMENT LYSATE EXTRACT.

Insufficient Data / SKIN CONDITIONING

Pantoea Agglomerans Ferment Lysate Extract is a bioactive ingredient derived from the controlled fermentation of the Gram-negative bacterium, Pantoea agglomerans. This bioprocess transforms high-molecular weight compounds into more readily absorbable, lower-molecular weight components, resulting in a rich lysate. It contains a beneficial blend of intracellular and extracellular metabolites, enzymes, peptides, and polysaccharides, among other components, designed for topical application.

Summary

Skin Conditioning Anti-inflammatory Skin Barrier Support Immune Modulating

Science

Mechanism of Action

The fermentation of Pantoea agglomerans yields a lysate rich in diverse bioactive compounds, including lipopolysaccharides (LPS). LPS from this extract has demonstrated significant anti-inflammatory effects, with potential to inhibit skin lesions associated with atopic dermatitis. Furthermore, the extract promotes human keratinocyte migration, supporting skin repair and regeneration. It may also modulate the skin's innate immune responses by binding to Toll-like Receptor 4 (TLR4) and acting on Langerhans cells, thereby helping to suppress allergic reactions and strengthen skin defense.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

While the optimal pH for Pantoea agglomerans bacterial growth is between pH 7.0 and 8.0, the specific optimal pH range for the stability and efficacy of Pantoea Agglomerans Ferment Lysate Extract in cosmetic formulations is not currently available.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) has not specifically evaluated Pantoea Agglomerans Ferment Lysate Extract. However, related ferment lysate ingredients are generally considered safe for cosmetic use. Although live Pantoea agglomerans can act as an opportunistic pathogen, this extract is a highly processed ingredient composed of non-viable bacterial fragments and their beneficial metabolites, thereby mitigating concerns associated with live bacteria. A specific glycolipid-containing extract derived from Pantoea agglomerans fermentation has been designated 'Generally Recognized as Safe' (GRAS) by the FDA for dietary supplements, further supporting the safety of its non-viable components.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While mechanistic studies reveal promising anti-inflammatory, skin repair, and immune-modulating properties, a lack of specific human clinical efficacy data for topical application means more research is required to fully assess its value in precision skincare formulations.

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