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Moumoujus

PANTOEA AGGLOMERANS EXTRACT.

Insufficient Data / SKIN CONDITIONING

Pantoea Agglomerans Extract, derived from a bacterium, contains lipopolysaccharide components that show promise in reducing skin inflammation and supporting cellular regeneration. It is being explored for its capacity to maintain skin barrier integrity and soothe reactive skin conditions.

Summary

Skin conditioning Anti-inflammatory Tissue regeneration support Immunomodulation

Science

Mechanism of Action

This extract's mechanism primarily involves its lipopolysaccharide (LPSp), which directly interacts with Toll-like receptor 4 (TLR4) on human epidermal cells, promoting their migration and potentially accelerating tissue repair. Additionally, a low-molecular-mass lipopolysaccharide (IP-PA1) from this extract exhibits anti-inflammatory effects by activating macrophages and regulating the Th1/Th2 immune system balance, which is crucial for maintaining skin homeostasis and mitigating conditions like atopic dermatitis.

Research

Clinical Evidence

Medium confidence
Effective range 0.01–0.1%
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

Pantoea Agglomerans Extract is not widely used in cosmetic formulations to the extent of being considered a 'dusted' ingredient. Its current application appears to be based on specific research interest rather than broad, low-concentration inclusion for marketing purposes.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Specific optimal pH ranges for the stability of Pantoea agglomerans extract in cosmetic formulations are not readily available. While research on the live bacterium indicates growth across a pH range of 4.5-8.6, this does not directly provide stability data for the purified extract.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Pantoea Agglomerans Extract has not been formally reviewed by cosmetic safety bodies such as the CIR, SCCS, or FDA for its use in cosmetic products. The live bacterium, Pantoea agglomerans, is classified as a biosafety level 2 (BL-2) organism due to its potential as an opportunistic human pathogen; however, this classification applies to the live organism, not necessarily a purified extract. Comprehensive public safety data, including GHS classifications or detailed toxicity for the cosmetic extract, is currently limited.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While preclinical data suggest compelling anti-inflammatory and regenerative capabilities for sensitive skin, the absence of comprehensive human topical clinical trials and regulatory safety assessments for cosmetic use warrants a cautious approach and further investigation.

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