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PANTHENYL TRIACETATE.

Valuable CAS 94089-18-6 / ANTISTATIC, HAIR CONDITIONING

Panthenyl Triacetate (PTA) is an oil-soluble ester of pro-vitamin B5, meticulously engineered for superior skin penetration and a prolonged release of panthenol. This compound actively stimulates fundamental cellular metabolic pathways, encompassing both energy production and lipid synthesis, thereby supporting comprehensive skin regeneration and vitality.

Summary

Skin Regeneration Wound Healing Soothing Hydrating Revitalizing Metabolism Stimulant Antistatic Hair Conditioning

Science

Mechanism of Action

As a synthetic, oil-soluble ester derived from panthenol (pro-vitamin B5), Panthenyl Triacetate converts into active panthenol within the skin via de-acetylation upon topical application. This mechanism facilitates deeper epidermal penetration and ensures a sustained release of the beneficial pro-vitamin. Its primary action involves stimulating key metabolic processes: it activates energetic pathways like glycolysis and the citric acid cycle, and promotes synthesis pathways crucial for isoprenoids and lipid production. This intricate metabolic engagement underpins its contributions to skin regeneration, effective wound healing, soothing relief, hydration, and overall revitalization.

Research

Clinical Evidence

High confidence
Effective range 2–3%
Optimal

2%

Key findings

  1. 01 At a 2% concentration, Panthenyl Triacetate stimulates energetic pathways (glycolysis, citric acid cycle) and synthesis pathways (isoprenoids, lipid synthesis) in human skin biopsies, demonstrating increased activity over panthenol over time.
  2. 02 A double-blind clinical study showed a statistically significant improvement in wound healing within 72 hours when using a 3% concentration of Panthenyl Triacetate, compared to a saline treatment.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH 5 – 8
0 7 14

Stability

Panthenyl Triacetate, as an acetylated derivative of Vitamin B5, exhibits superior stability against hydrolysis within cosmetic formulations compared to raw panthenol, which contributes to product shelf-life and efficacy.

Conflicts

  • Must not be used in cosmetic products where N-nitroso compounds may form, particularly if ingredients containing residual amines as impurities are present.
  • Avoid exceeding recommended dosage to prevent potential adverse effects.

Safety

Safety Profile

CIR Status
Safe as used
Max tested
2%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel affirmed Panthenyl Triacetate's safety, concluding it is safe for use in current cosmetic concentrations. The maximum reported concentration for Panthenyl Triacetate in leave-on products is up to 2%. While considered safe, formulators are cautioned against using it in conjunction with ingredients that may introduce residual amines, which could lead to N-nitroso compound formation.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Panthenyl Triacetate is a valuable pro-vitamin B5 derivative offering enhanced skin penetration and sustained metabolic stimulation, proving highly effective for regeneration, wound healing, and comprehensive skin revitalization at concentrations up to 2%.

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