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Moumoujus

PANTHENYL HYDROXYPROPYL STEARDIMONIUM CHLORIDE.

Valuable CAS 132467-76-6 / ANTISTATIC, HAIR CONDITIONING

Panthenyl Hydroxypropyl Steardimonium Chloride is a panthenol-derived quaternary ammonium salt engineered to provide advanced skin and hair conditioning. It works by attracting and retaining moisture, forming a protective barrier to promote a smoother, softer skin texture and improved hair manageability.

Summary

Antistatic Hair conditioning Skin conditioning

Science

Mechanism of Action

As a positively charged quaternary ammonium salt, this ingredient efficiently adheres to the skin's surface, acting as a potent conditioning agent. Its panthenol (pro-vitamin B5) component significantly enhances stratum corneum hydration, minimizes transepidermal water loss, and boosts skin softness and elasticity. It may also stimulate fibroblast proliferation and exhibit anti-inflammatory effects.

Research

Clinical Evidence

High confidence
Effective range 0.1–4%
Optimal

N/A

Key findings

  1. 01 Formulations containing 1.0% and 5.0% Panthenol, a key component of this ingredient, demonstrated significant improvements in skin barrier function and reductions in transepidermal water loss (TEWL) after 30 days of application. Specifically, 1.0% Panthenol was effective in maintaining skin integrity through an enhanced protective effect.
  2. 02 At a concentration of 0.3%, Panthenyl Hydroxypropyl Steardimonium Chloride exhibited superior cling ability to hair compared to 1.0% D-Panthenol, indicating strong adherence properties.

Transparency

Dusting Analysis

Not commonly dusted

No data regarding 'dusting' or potential for over-formulation beyond the noted utilization rates was found in the provided research.

The Formula

Formulation

Solubility
Water
Optimal pH 3 – 9
0 7 14

Stability

This ingredient is stable across a pH range of 3 to 9. While it possesses heat tolerance, it is advisable to avoid temperatures exceeding 80°C. For dissolution, it should be gradually introduced to water with continuous stirring for approximately 15 minutes. If the product's pH is above 7.0, it requires adjustment to below 7.0 using an acid such as citric or lactic acid.

Safety

Safety Profile

CIR Status
Safe as used
Max tested
4%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has concluded that Panthenyl Hydroxypropyl Steardimonium Chloride, along with Panthenol and other derivatives, is safe for use in cosmetics within current practices and concentrations, with observed utilization rates typically ranging from 0.1% to 4.0%. Stearic acid, a component, is Generally Recognized As Safe (GRAS) by the FDA for cosmetic use. However, for certain over-the-counter (OTC) drug products, related panthenol compounds had insufficient safety data to establish generally-recognized-as-safe-and-effective status. Irritancy for skin is low, but high for eyes.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

This panthenol-derived conditioning agent is valuable for enhancing skin hydration, barrier function, and texture across all skin types due to its strong adherence, established safety profile, and moisture-retaining properties.

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