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Moumoujus

PANICUM MILIACEUM EXTRACT.

Valuable CAS 90082-36-3 / SKIN CONDITIONING

Panicum Miliaceum Extract is a multi-functional botanical ingredient derived from millet, recognized for its ability to significantly enhance skin firmness and elasticity. It actively supports the skin's natural anti-aging processes, fortifies the cutaneous barrier, and offers calming anti-inflammatory and antioxidant benefits.

Summary

Skin Conditioning Smoothing Firming Anti-aging Barrier Reinforcement Anti-inflammatory Antioxidant Moisturizing Wound Healing

Science

Mechanism of Action

At a cellular level, Panicum Miliaceum Extract, particularly its compound miliacin, enhances cell metabolism and proliferation, facilitating tissue rejuvenation and activating skin repair pathways. It specifically stimulates the expression of elafin in the skin dermis, crucial for improving skin firmness, smoothing texture, tightening, plumping, and restoring elasticity and tone. The extract reinforces the skin barrier by promoting corneocyte envelope formation and stimulating keratinocyte differentiation, while also enhancing dermal-epidermal junction components like laminin for sustained epidermal renewal. Its carbohydrate content contributes to moisture retention, forming a protective film against environmental stressors. Rich in amino acids, vitamins, and minerals, it provides anti-aging effects, helps reduce blemishes, and exerts anti-inflammatory action by reducing nitric oxide production, alongside antioxidant properties that prevent lipid peroxidation and regulate redox reactions.

Research

Clinical Evidence

Medium confidence
Effective range 0.001–5%
Optimal

N/A

Key findings

  1. 01 Stimulates elafin expression, contributing to skin firming, enhanced elasticity, anti-aging effects, and reinforcement of the cutaneous barrier. Effective concentrations range from 0.001% to 5%, with preferred ranges including 0.001%-0.5%, 0.005%-0.1%, and notably 0.01%-0.05%.
  2. 02 Demonstrated anti-inflammatory effects by significantly reducing nitric oxide production in macrophages in vitro, with no observed cytotoxicity.
  3. 03 An in vitro application of a complex containing millet extract increased mRNA levels of antioxidant enzymes (catalase, SOD1) and growth factors (IGF-1, VEGF, FGF7) in human immortalized dermal papilla cells, concurrently decreasing inflammatory cytokine mRNA levels (IL-6, TNFα), indicating potential for suppressing oxidative stress and inflammation.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH 3 – 6
0 7 14

Stability

The extract maintains stability within a pH range of 3.0 to 6.0, with specific stability noted between 3.0 and 4.0.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

No official safety assessments from CIR, SCCS, or FDA were identified in the research. The ingredient is generally considered non-irritating and 'Irritant Free', with no identified hazards under GHS Classification (OSHA HCS). Data for oral, parenteral, dermal, and inhalation toxicity are not comprehensively determined.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Panicum Miliaceum Extract is a valuable ingredient, demonstrating broad efficacy in enhancing skin firmness, elasticity, and barrier function, while also offering significant anti-inflammatory and antioxidant benefits suitable for diverse skin types.

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References

Sources