Science
Mechanism of Action
This extract primarily functions by mitigating oxidative stress through its antioxidant capabilities, effectively scavenging free radicals. It exerts anti-inflammatory effects by suppressing inflammatory responses and decreasing the secretion of pro-inflammatory cytokines. Additionally, it demonstrates anti-aging potential by stimulating the production of type I pro-collagen in human dermal fibroblasts and inhibiting MMP-1 expression, an enzyme implicated in collagen breakdown, ultimately contributing to improved skin elasticity and barrier function.
Research
Clinical Evidence
Medium confidenceN/A
Transparency
Dusting Analysis
While the CIR Expert Panel concluded that Panax Ginseng Root and its extracts are safe for cosmetic use, specific reported usage data for Panax Notoginseng Root Extract is limited. The maximum reported concentration to the FDA was 0.0004% specifically in dentifrices, with no reported uses in other cosmetic categories. This low reported percentage does not serve as a general 'red flag' for topical formulations but rather indicates a lack of extensive reported usage data for higher concentrations in the broader cosmetic market.
The Formula
Formulation
Stability
Key active constituents, Panax Notoginseng Saponins (PNS), maintain stability in formulations with a pH exceeding 4.5. Additionally, fermented Panax notoginseng broths have demonstrated stability in pH and soluble solid content over a four-week period.
Safety
Safety Profile
The CIR Expert Panel concluded that Panax Ginseng Root and its extracts are safe for cosmetic and personal care products. Dermal studies confirm that ingredients derived from Panax ginseng roots are neither irritants nor sensitizers. Fermented Panax notoginseng broths also exhibit non-irritating properties in various assays. The EWG Skin Deep database rates Panax Notoginseng Extract with low concerns regarding cancer, allergies/immunotoxicity, and developmental/reproductive toxicity. It is important to note that concerns regarding oral consumption during pregnancy and breastfeeding, due to potential estrogenic activity, pertain specifically to internal intake and are not applicable to topical application, for which no specific pregnancy safety data is available.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Panax Notoginseng Root Extract is a valuable ingredient, demonstrating significant in vitro antioxidant, anti-inflammatory, and collagen-boosting properties, coupled with a favorable topical safety profile, making it beneficial for comprehensive skin health and targeted anti-aging formulations.
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