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Moumoujus

PANAX NOTOGINSENG LEAF/STEM EXTRACT.

Valuable CAS 94279-78-4 / ASTRINGENT

Derived from the leaves and stems of the Panax Notoginseng plant, this extract is a multifaceted active ingredient. It offers robust antioxidant defense, contributes to a more even skin tone, and supports overall skin health and regeneration.

Summary

Antioxidant Anti-aging Skin brightening Skin conditioning Anti-inflammatory Hydrating Barrier strengthening Collagen protection Skin regeneration

Science

Mechanism of Action

Panax Notoginseng Leaf/Stem Extract functions by neutralizing free radicals and inhibiting the production of reactive oxygen species (ROS), thereby mitigating oxidative stress. It reduces malondialdehyde (MDA) content and enhances the activity of key antioxidant enzymes like SOD, GSH-Px, and CAT, which collectively combat skin aging and promote cellular regeneration. The extract's bioactive ginsenosides reduce inflammation, improve skin texture and elasticity, strengthen the skin barrier, enhance hydration, and offer protection against environmental aggressors, including pollution and UV radiation. It also contributes to preventing collagen degradation.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Reduced 500 µM H2O2-induced cell death in primary cultures of rat cortical astrocytes.
  2. 02 Demonstrated tyrosinase inhibition, suggesting skin-whitening potential.
  3. 03 Showed inhibition of melanin synthesis, indicating skin-whitening potential.
  4. 04 Exhibited ABTS free radical removal, signifying antioxidant activity, particularly attributed to stem leaf flavonoids.

Transparency

Dusting Analysis

Not commonly dusted

No specific data suggests this ingredient is commonly 'dusted' or used in ineffectual concentrations relative to established clinical efficacy benchmarks.

The Formula

Formulation

Solubility
Water
Optimal pH 4.6 – 5.2
0 7 14

Stability

Fermentation broths of Panax notoginseng have shown stability within a weakly acidic pH range of 4.6 to 5.2 over a 0-4 week period. Microencapsulation of the stem and leaf extract can further enhance its stability.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Low

No specific CIR or SCCS assessment is available for PANAX NOTOGINSENG LEAF/STEM EXTRACT. However, fermentation broths have demonstrated suitable safety for cosmetic use in vascular response tests, similar to a negative control. General Panax notoginseng extract (often from the root) is rated 'LOW' by EWG for common concerns. It is crucial to note that oral Panax notoginseng is considered potentially unsafe during pregnancy/breastfeeding and for hormone-sensitive conditions due to possible estrogenic effects and animal study findings; these oral safety considerations may not directly translate to topical leaf/stem extract application, but caution is advised in the absence of specific topical safety data for these groups.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Panax Notoginseng Leaf/Stem Extract is a valuable ingredient, demonstrating significant antioxidant, skin-brightening, and anti-aging potential through various in vitro studies, with reported low irritancy and broad skin type compatibility.

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