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PANAX GINSENG BUD EXTRACT.

Valuable CAS 84650-12-4 / HUMECTANT, SKIN CONDITIONING

Panax Ginseng Bud Extract is a multifaceted botanical ingredient renowned for its comprehensive skin benefits. Rich in active compounds, it significantly contributes to anti-aging by boosting collagen synthesis and offers robust antioxidant protection, while also enhancing hydration and promoting a more even skin tone.

Summary

Antioxidant Skin Protecting Anti-aging Collagen Boosting Hydrating Anti-inflammatory Brightening Emollient Tonic

Science

Mechanism of Action

This extract revitalizes skin through several pathways. It enhances cellular nutrition and metabolism by optimizing microcirculation. Crucially, it stimulates fibroblasts to increase Type I collagen synthesis, partly via the TGF-β signaling pathway, and concurrently reduces collagen degradation by inhibiting enzymes such as MMP-1. Its potent antioxidant capacity neutralizes free radicals, safeguarding skin from environmental aggressors like UV radiation and pollution. Furthermore, its polysaccharide content strengthens the skin barrier, reducing transepidermal water loss and improving hydration. It also exhibits anti-inflammatory properties, helps diminish hyperpigmentation by reducing melanin production, and offers adaptogenic defense against urban stressors.

Research

Clinical Evidence

High confidence
Effective range 0.000001–0.05%
Optimal

0.05%

Key findings

  1. 01 A clinical study on human volunteers demonstrated significant improvement in fine lines and wrinkles over 8 weeks with a 0.05% concentration of ginseng extract. This study identified ginsenoside Rb3, abundant in leaves, as a key compound involved in collagen synthesis.
  2. 02 An in vitro study on human skin fibroblasts showed a 55.1% increase in Type I collagen synthesis when exposed to 0.01% (100 µg/mL) of ginseng extract.
  3. 03 An in vitro pilot study on human dermal fibroblasts determined 0.000001% (10 ng/mL) as the optimal concentration for stimulating both fibroblast proliferation and collagen synthesis.

Transparency

Dusting Analysis

Not commonly dusted
Min. effective
0.5%
Red flag below
0.5%

Effective concentrations range from a very low 0.000001% for in vitro fibroblast stimulation to 0.05% for clinically observed anti-wrinkle effects. While the maximum safe concentration is established at 0.5%, concentrations significantly above 0.05% may not yield proportionally greater benefits, though they remain within safe usage limits up to 0.5%.

The Formula

Formulation

Solubility
Water
Optimal pH 6 – 8
0 7 14

Stability

Ginsenosides, the primary active compounds, demonstrate optimal stability within a pH range of 6.0-8.0. Stability significantly decreases under strongly acidic conditions, such as pH 3.0.

Conflicts

  • Strongly acidic pH (e.g., below 6.0) can lead to significant degradation of active ginsenosides.

Safety

Safety Profile

CIR Status
Safe as used
Max tested
0.5%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel concluded that Panax spp. root-derived ingredients, including Panax Ginseng Root Extract, are safe for cosmetic use up to 0.5%. Dermal studies indicate a low risk of irritation or sensitization. While no specific SCCS review for 'PANAX GINSENG BUD EXTRACT' was found, it is generally well-tolerated, though individual sensitivities may vary, making patch testing advisable.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Panax Ginseng Bud Extract is a valuable ingredient, clinically shown to reduce visible signs of aging and enhance overall skin health through its potent antioxidant, collagen-boosting, and hydrating properties, with a favorable safety profile across all skin types.

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