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Moumoujus

PALMITOYL TRIPEPTIDE-8.

Valuable CAS - / SKIN CONDITIONING

This biomimetic peptide is precisely engineered to interrupt inflammatory cascades, effectively diminishing redness and soothing irritated skin. It reinforces the skin's natural barrier function, promoting a resilient and calm epidermal environment.

Summary

Soothing Anti-inflammatory Redness Reduction Skin Barrier Fortification Dry Skin Relief Edema Reduction Rosacea Symptom Management

Science

Mechanism of Action

Palmitoyl Tripeptide-8 exerts its calming effects by directly targeting key inflammatory pathways. It acts as a selective competitive inhibitor for the melanocortin 1 receptor (MC1-R), blocking α-melanocyte-stimulating hormone (α-MSH) and significantly reducing the release of pro-inflammatory cytokines such as IL-1, IL-8, and TNF-α. Additionally, it suppresses Substance P release, thereby mitigating neurogenic inflammation, vasodilation, edema, and sensations of burning or stinging. The peptide further fortifies skin barrier function by increasing filaggrin synthesis by 17.8% and enhancing β-defensin secretion, supporting overall skin homeostasis.

Research

Clinical Evidence

High confidence
Effective range 0.0005–2.5%
Optimal

N/A

Key findings

  1. 01 In vivo human tests demonstrated a 52% reduction in erythema area within 48 hours.
  2. 02 A cosmetic product containing Palmitoyl Tripeptide-8 showed statistically significant improvement in redness, flushing, skin tone, and overall rosacea severity after 8 weeks of use in patients.
  3. 03 In a study with 57 male users, 50% with sensitive skin, over 90% found skin had less redness, and over 70% felt better overall. This study utilized a concentration range of 1.0-2.5%.
  4. 04 In vitro, Palmitoyl Tripeptide-8 inhibited IL-8 production by 64% in IL-1 stimulated fibroblasts at a concentration of 10^-7 M.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 6.5 – 7.5
0 7 14

Stability

This peptide maintains optimal stability within a neutral pH range of 6.5 to 7.5, as it hydrolyzes in acidic conditions. It is sensitive to heat, with temperatures exceeding 40°C needing to be avoided. For long-term storage, refrigeration at 2–8°C under a dry nitrogen atmosphere is recommended to prevent oxidation.

Conflicts

  • acidic conditions
  • high heat

Safety

Safety Profile

CIR Status
Safe as used
Sensitization risk Low

Palmitoyl Tripeptide-8 was included in a 2012/2013 Cosmetic Ingredient Review (CIR) safety assessment for 'Palmitoyl Oligopeptides', which concluded these ingredients are safe in cosmetics at current use practices and concentrations. It is also listed in the FDA's Voluntary Cosmetic Registration Program (VCRP) as of 2012. It is generally regarded as non-irritating and suitable for most skin types at typical cosmetic doses.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Palmitoyl Tripeptide-8 is a valuable peptide renowned for its potent anti-inflammatory and soothing properties, effectively reducing redness and strengthening the skin barrier, particularly beneficial for sensitive and reactive skin types.

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