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Moumoujus

PALMITOYL TRIPEPTIDE-71 AMIDE.

Insufficient Data / SKIN CONDITIONING

PALMITOYL TRIPEPTIDE-71 AMIDE is a synthetic biomimetic peptide engineered to emulate natural growth factors, targeting cellular pathways to revitalize and regenerate skin. It is designed to enhance the production of critical structural proteins like collagen and elastin, leading to improved skin tone, texture, and firmness, while actively reducing the appearance of wrinkles.

Summary

Anti-aging agent Skin conditioner Collagen booster Elastin booster Wrinkle reducer Skin regenerator Firming agent Texturizer

Science

Mechanism of Action

This peptide functions as a fibroblast growth factor (FGF) agonist, enabling its penetration into the dermis where it interacts with FGF receptors. This interaction stimulates the proliferation and differentiation of both keratinocytes and dermal fibroblasts. It additionally activates key intracellular signaling pathways, specifically ERK1/2 and Akt, which are vital for cell proliferation, differentiation, and survival within dermal tissues. Furthermore, PALMITOYL TRIPEPTIDE-71 AMIDE promotes neo-angiogenesis, significantly increasing the tubular formation of endothelial cells and thereby enhancing blood microcirculation in the skin. These combined actions collectively boost skin regeneration, augment collagen and elastin synthesis, and contribute to visible wrinkle reduction.

Research

Clinical Evidence

Low confidence
Effective range 0.001–5%
Optimal

N/A

Key findings

  1. 01 Studies on Palmitoyl sh-Tripeptide-1 Amide demonstrated skin rejuvenation, improvements in tone and texture, enhanced collagen and elastin production, and reduction in wrinkles.
  2. 02 Research involving Palmitoyl Tripeptide-1 indicated stimulation of collagen production, reduced appearance of fine lines, wrinkles, and sagging, enhanced skin firmness and elasticity, and support for skin healing and regeneration.
  3. 03 A cream formulation containing Palmitoyl Tripeptide-3/5 demonstrated dose-dependent wrinkle reduction.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH 4 – 6.5
0 7 14

Stability

The stability of similar peptides, such as Palmitoyl sh-Tripeptide-1 Amide, is enhanced by the incorporation of a palmitic group and amide modification. An optimal pH range of 4.0-6.5 has been identified for the stability of related Palmitoyl Tripeptide-1.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Unknown

A direct safety assessment by the Cosmetic Ingredient Review (CIR) specifically for PALMITOYL TRIPEPTIDE-71 AMIDE is currently unavailable. However, related peptides like Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7 have been reviewed by CIR and deemed safe for use within current cosmetic practices. While Palmitoyl Tripeptide-1 is generally considered non-toxic at recommended concentrations (2-5%) and Palmitoyl sh-Tripeptide-1 Amide is also noted as safe, there are conflicting reports specifically for PALMITOYL TRIPEPTIDE-71 AMIDE regarding irritation potential, with some sources indicating a 'likelihood of irritation' while others state it is 'generally non-irritating'.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While PALMITOYL TRIPEPTIDE-71 AMIDE exhibits significant potential for anti-aging and skin regeneration based on its sophisticated mechanism and the reported efficacy of closely related peptides, comprehensive direct clinical data and specific safety assessments for this exact compound are currently limited, necessitating further dedicated research for a definitive evaluation.

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