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PALMITOYL TRIPEPTIDE-56.

Valuable / SKIN CONDITIONING

PALMITOYL TRIPEPTIDE-56 is a synthetic matrikine lipopeptide engineered to enhance skin's youthful appearance by bolstering the production of critical extracellular matrix components, including various collagen types and fibronectin. This action leads to improved skin structure, density, and firmness, with clinical studies demonstrating a visible reduction in multiple types of facial wrinkles.

Summary

Skin Conditioning Anti-aging Firming Collagen Boosting

Science

Mechanism of Action

PALMITOYL TRIPEPTIDE-56, specifically its active N-Prolyl Palmitoyl Tripeptide-56 Acetate form, functions as a sophisticated matrikine lipopeptide. It operates by significantly enhancing the expression and production of key extracellular matrix (ECM) components, such as collagen types I, III, IV, and VI, and fibronectin. This peptide re-establishes crucial connections between fibroblast nuclei and the ECM, thereby stimulating both the production and maturation of collagen fibers. Furthermore, it impacts pathways regulating collagen synthesis and the actin cytoskeleton, while upregulating transcription factors like FOXO and stress-response proteins such as sestrins, which are linked to cellular longevity. These comprehensive actions collectively contribute to enhanced skin structure, density, and firmness, ultimately reducing the appearance of wrinkles.

Research

Clinical Evidence

High confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 An in vivo human volunteer study demonstrated significant reduction in marionette lines, frown lines, vertical lines, and a visible decrease in crow's feet after six weeks of application. The specific peptide concentration used for these wrinkle reduction effects was not detailed.
  2. 02 Preliminary in vitro and formulation studies utilizing emulsions containing 0.5% to 2% N-Prolyl Palmitoyl Tripeptide-56 Acetate (as part of a complex with Bakuchiol) indicated good antioxidant activity and suitability for topical products with potential anti-aging effects.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 4.8 – 5.54
0 7 14

Stability

Emulsions containing N-Prolyl Palmitoyl Tripeptide-56 Acetate demonstrated optimal stability within a pH range of 4.8 to 5.54, ensuring compatibility with the skin's natural pH (4-6).

Synergies

  • Bakuchiol (enhances antioxidant activity and potential anti-aging effects when combined in formulations)

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Low

PALMITOYL TRIPEPTIDE-56 (as N-Prolyl Palmitoyl Tripeptide-56 Acetate) is generally considered safe for topical use in cosmetic formulations, exhibiting a low irritancy profile. However, regulatory assessments from bodies like CIR currently indicate 'insufficient data'. The FDA UNII is 5YX5BR41EQ. EWG notes it as 'restricted' for EWG VERIFIED products without adequate substantiation, awaiting further industry or government recommendations.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

PALMITOYL TRIPEPTIDE-56 is a valuable anti-aging peptide demonstrating significant in vivo wrinkle reduction by enhancing extracellular matrix components, suitable for all skin types despite pending comprehensive regulatory assessment.

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