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PALMITOYL TRIPEPTIDE-42.

Valuable CAS - / SKIN CONDITIONING

Palmitoyl Tripeptide-42 is a synthetic peptide conjugated with palmitic acid, serving as a skin-conditioning agent. It is designed to enhance skin elasticity and reduce the appearance of wrinkles by supporting the skin's natural collagen production. The palmitic acid component optimizes its penetration and bioavailability within the skin.

Summary

Skin Conditioning Anti-aging Elasticity Enhancer Firming

Science

Mechanism of Action

This tripeptide derivative primarily operates by activating skin fibroblasts, stimulating them to increase the synthesis of crucial structural proteins such as collagen. This mechanism is key to improving skin firmness, enhancing elasticity, and diminishing the visible signs of aging like fine lines and wrinkles. The integrated palmitic acid moiety plays a vital role in facilitating deeper skin barrier penetration, thereby boosting the peptide's stability and ensuring its effective delivery to target cells.

Research

Clinical Evidence

Low confidence
Effective range 0.0001–0.003%
Optimal

0.001%

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 4 – 6.5
0 7 14

Stability

Specific optimal pH and detailed stability data for Palmitoyl Tripeptide-42 are limited; however, drawing from related peptides like Palmitoyl Tripeptide-1, a stability range of pH 4.0-6.5 is suggested. For best stability, it is recommended to incorporate this ingredient into formulations at temperatures below 40 °C and typically during the final stages of manufacturing.

Safety

Safety Profile

CIR Status
Safe as used
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has concluded that Palmitoyl Tripeptide-42 is safe for use in cosmetic products under current practices, provided it is formulated to be non-irritating. It is listed in the FDA's Voluntary Cosmetic Registration Program (VCRP). While no specific maximum concentration is stipulated, related peptides are customarily used in concentrations ranging from 0.0001% to 0.003%, with concentrations below 0.001% being common practice.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Palmitoyl Tripeptide-42 is a valuable skin-conditioning agent that supports dermal collagen production to enhance skin elasticity and mitigate wrinkle appearance, offering broad skin compatibility and a favorable safety profile.

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