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Moumoujus

PALMITOYL TRIPEPTIDE-1.

Valuable CAS 147732-56-7 / SKIN CONDITIONING

A synthetic peptide, Palmitoyl Tripeptide-1 acts as a cellular messenger, signaling the skin to enhance its repair and rejuvenation processes. It is instrumental in boosting the skin's structural integrity, leading to improved firmness and a visibly smoother complexion.

Summary

skin conditioning anti-aging collagen stimulating elasticity enhancing firming wrinkle reducing hydrating antioxidant

Science

Mechanism of Action

This matrikine peptide works by mimicking fragments of collagen, prompting fibroblasts to increase the production of essential extracellular matrix components such as collagen types I and III, fibronectin, and hyaluronic acid. This activity reinforces skin structure, enhancing firmness and elasticity. Furthermore, Palmitoyl Tripeptide-1 helps preserve skin integrity by inhibiting matrix metalloproteinases (MMPs), enzymes responsible for collagen degradation. It also supports skin hydration, aids in visible damage regeneration, and exhibits antioxidant properties by neutralizing reactive species that can harm collagen and elastin.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Commonly dusted
Min. effective
0.001% (10 ppm) for pure peptide%

While Palmitoyl Tripeptide-1 has demonstrated efficacy as part of well-formulated blends like Matrixyl 3000, its typical standalone use concentration is reported to be less than 0.001%. This extremely low threshold makes it susceptible to 'dusting,' where it is included at negligible percentages (e.g., far below 0.001%) in products to simply appear on the ingredient list for marketing purposes, rather than to deliver a functional benefit.

The Formula

Formulation

Solubility
Both
Optimal pH 4 – 6.5
0 7 14

Stability

No specific stability notes provided beyond optimal pH range.

Safety

Safety Profile

CIR Status
Safe as used
Max tested
0.001%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel deemed Palmitoyl Tripeptide-1 safe for use in personal care products at concentrations up to 0.001%. It is generally considered non-toxic with low irritation potential. A specific ocular irritation study involving a trade-name mixture (0.01%) of palmitoyl oligopeptide noted it as a slight irritant to rabbit eyes, suggesting careful formulation around the eye area.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Palmitoyl Tripeptide-1 is a valuable signaling peptide, renowned for its ability to stimulate collagen synthesis and improve skin firmness, elasticity, and overall texture, making it an excellent component for advanced anti-aging formulations.

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