Science
Mechanism of Action
This innovative peptide operates by mimicking natural anti-inflammatory processes, actively suppressing key pro-inflammatory cytokines such as TNF-α and IL-1, and blocking NF-kB activation, which in turn reduces leukocyte adhesion to endothelial cells. It also prevents UVA-induced degradation of the dermal extracellular matrix proteins, thereby offering protection against photoaging. Furthermore, it inhibits angiogenesis to reduce skin redness and enhances the skin's natural barrier function, creating a robust defense against external aggressors. Its comprehensive action contributes to improved skin texture and overall skin health.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The inclusion of a palmitoyl group and amide modification significantly enhances the stability of this peptide within cosmetic formulations, ensuring its integrity and efficacy over time.
Safety
Safety Profile
While a direct review by CIR, SCCS, or FDA for PALMITOYL SH-TRIPEPTIDE-4 AMIDE is not explicitly documented, manufacturers attest to its safety and efficacy, supported by numerous repeated-dose toxicity tests. Related palmitoyl peptides, such as palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7, have been deemed safe by CIR in cosmetic applications, typically at concentrations below 10 ppm. Palmitoyl pentapeptide-4 also holds a safety clearance, suggesting a favorable safety profile for this class of peptides.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Palmitoyl SH-Tripeptide-4 Amide is a valuable multi-functional peptide, offering significant anti-inflammatory, anti-aging, and skin barrier-enhancing benefits with broad skin compatibility and a low risk of irritation.
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References
Sources