Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

PALMITOYL SH-TRIPEPTIDE-1 AMIDE.

Valuable / HUMECTANT, SKIN CONDITIONING

A cutting-edge signaling peptide that acts as a fibroblast growth factor (FGF) agonist, Palmitoyl sh-Tripeptide-1 Amide is engineered to deeply rejuvenate the skin. It effectively boosts the production of essential skin proteins and significantly enhances microcirculation, leading to visible improvements in skin quality and reduced signs of aging.

Summary

Skin conditioning Anti-aging Wrinkle reduction Skin regeneration Collagen boosting Elastin boosting Improved skin tone Improved skin texture Improved microcirculation

Science

Mechanism of Action

Palmitoyl sh-Tripeptide-1 Amide operates by penetrating the dermis to specifically engage fibroblast growth factor (FGF) receptors. This interaction stimulates the proliferation and differentiation of both keratinocytes and dermal fibroblasts, key cellular components for skin health. Its mechanism involves activating the ERK1/2 and Akt signaling pathways, which are critical for cell survival, proliferation, and differentiation. Furthermore, this peptide promotes neo-angiogenesis, demonstrably increasing the formation of endothelial cell tubules and improving blood microcirculation within the skin. This cascade of actions results in enhanced collagen (specifically types I and III) and elastin synthesis, fostering comprehensive skin regeneration and a noticeable reduction in wrinkles. It also mimics natural collagen breakdown signals, prompting the skin's inherent repair processes and new collagen formation, potentially through the activation of transforming growth factor-beta (TGF-β) pathways, along with upregulating glycosaminoglycans (GAGs) and fibronectin.

Research

Clinical Evidence

Medium confidence
Effective range 1–2%
Optimal

Formulations containing 1-2% of Palmitoyl sh-Tripeptide-1 Amide have demonstrated significant skin rejuvenation.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH 4 – 6.5
0 7 14

Stability

The stability of Palmitoyl sh-Tripeptide-1 Amide in cosmetic formulations is enhanced by its palmitic group and amide modification. An optimal pH range of 4.0-6.5 is generally recommended, drawing guidance from stability data for Palmitoyl Tripeptide-1.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

While a specific CIR (Cosmetic Ingredient Review) safety assessment for PALMITOYL SH-TRIPEPTIDE-1 AMIDE (sequence Pal-Phe-Leu-Glu-NH2) has not been published, the related ingredient Palmitoyl Tripeptide-1 (sequence Pal-Gly-His-Lys) was reviewed by the CIR Expert Panel in 2014 and 2018. The CIR concluded that Palmitoyl Tripeptide-1 and similar peptides are safe under current practices of use and concentration, with reported maximum use concentrations in cosmetic products up to 0.002% (or less than 10 ppm) for Palmitoyl Tripeptide-1. General industry consensus suggests Palmitoyl sh-Tripeptide-1 Amide is considered safe for cosmetic use following established guidelines.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Palmitoyl sh-Tripeptide-1 Amide is a valuable peptide for advanced skincare, offering comprehensive anti-aging and regenerative benefits through robust cellular and microcirculatory mechanisms.

Related

Similar Ingredients

Finding similar ingredients…