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PALMITOYL SH-PENTAPEPTIDE-4.

Valuable / ANTIOXIDANT, SKIN CONDITIONING

PALMITOYL SH-PENTAPEPTIDE-4 is a meticulously engineered matrikine, a signaling peptide derived from collagen, designed to deeply penetrate the skin and activate its natural repair mechanisms. It is an efficacious component for formulations aimed at significant rejuvenation, visibly reducing the appearance of wrinkles and enhancing skin's structural integrity.

Summary

Anti-aging Skin-conditioning

Science

Mechanism of Action

Operating as a cellular messenger, PALMITOYL SH-PENTAPEPTIDE-4 stimulates the skin's inherent capacity for self-repair. Its precise action involves promoting the biosynthesis of key extracellular matrix proteins, including various types of collagen (I, III, IV), elastin, fibronectin, and hyaluronic acid. Concurrently, it moderates collagen breakdown by inhibiting collagenase and activates the TGF-β pathway, collectively fostering dermal repair, refining skin texture, and minimizing lines and wrinkles.

Research

Clinical Evidence

High confidence
Effective range 0.0003–0.005%
Optimal

0.0003%

Key findings

  1. 01 Demonstrated significant reduction in fine lines and wrinkles, alongside notable improvement in overall skin texture.
  2. 02 Led to significant improvement in wrinkle reduction, increased skin elasticity, and enhanced skin barrier function over 8-12 weeks, without reported irritation or adverse effects.
  3. 03 Applied twice daily for 28 days, resulted in a quantitative 18% decrease in fold depth, a 37% reduction in fold thickness, and a 21% increase in skin firmness.
  4. 04 Well tolerated as part of a moisturizer in a 12-week, double-blind, placebo-controlled clinical study.

Transparency

Dusting Analysis

Not commonly dusted

Effective concentrations for PALMITOYL SH-PENTAPEPTIDE-4 range from 0.0003% to 0.005%, demonstrating significant clinical results within this spectrum. These concentrations are well below the established maximum safe concentration of 0.012% for leave-on products, indicating that these effective doses are genuinely active and not indicative of 'dusting' at lower, ineffective levels.

The Formula

Formulation

Solubility
Both
Optimal pH 5 – 7
0 7 14

Stability

To maintain integrity, avoid temperatures exceeding 60°C. Delivery can be optimized by incorporating it into flexible liposomes.

Safety

Safety Profile

CIR Status
Safe as used
Max tested
0.012%
Sensitization risk Low

The Expert Panel for Cosmetic Ingredient Safety (CIR) has affirmed PALMITOYL SH-PENTAPEPTIDE-4 as safe for use in cosmetic formulations, consistent with current practices and concentrations. Both FDA and European Commission regulatory bodies approve its inclusion in cosmetic products, with a highest reported leave-on maximum concentration of 0.012% in facial, neck, and eye preparations.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

PALMITOYL SH-PENTAPEPTIDE-4 is a valuable peptide for advanced skincare formulations, effectively targeting multiple signs of aging through its proven ability to stimulate skin's regenerative processes and improve texture and elasticity.

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