Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

PALMITOYL PROLINE.

Valuable CAS 59441-32-6 / HAIR CONDITIONING, SKIN CONDITIONING

Palmitoyl Proline is a multi-functional lipoamino acid that significantly enhances skin's structural integrity, moisture retention, and resilience. It is prized for its ability to soothe irritation, reduce the appearance of aging, and promote a more even, radiant complexion.

Summary

Skin-conditioning Emollient Antioxidant Moisture retention Collagen support Soothing Brightening Anti-aging Barrier function enhancement Tone-evening

Science

Mechanism of Action

This ingredient is a precise fusion of palmitic acid and the amino acid proline. Proline is a critical building block for collagen, directly supporting its formation, essential for maintaining skin elasticity, firmness, and the reduction of fine lines and wrinkles. It also plays a key role in skin healing and tissue repair, rejuvenating fatigued skin. The palmitic acid component fortifies the skin's natural barrier, preventing moisture loss and optimizing hydration. As Sodium Palmitoyl Proline, its unique amphiphilic structure enables it to interact with both lipid and aqueous phases, delivering targeted skin-conditioning benefits. It functions as an antioxidant, mitigating oxidative stress, calming irritation, and visibly diminishing stress-induced hyperpigmentation for enhanced skin comfort.

Research

Clinical Evidence

High confidence
Effective range N/A
Optimal

3%

Key findings

  1. 01 When incorporated into complexes, often with Nymphaea alba flower extract, at concentrations around 3%, Palmitoyl Proline demonstrates significant soothing, brightening, and anti-aging effects in finished cosmetic formulas.
  2. 02 A serum containing Sodium Palmitoyl Proline as part of a 5% Peptide Blend, along with a 3% Water Lily Complex, showed an instant reduction in redness. Clinical trials further reported a significant decrease in fine lines and wrinkles after 4 weeks, and noticeable improvement in skin tone after 8 weeks of consistent use.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

While Sodium Palmitoyl Proline is sparingly soluble in water, its amphiphilic properties allow for efficient integration into formulations. It can be effectively handled and incorporated via glycol-based concentrates or microemulsions, interacting favorably with both lipid and aqueous phases for enhanced stability.

Synergies

  • Nymphaea alba flower extract
  • Water Lily Complex

Safety

Safety Profile

CIR Status
Safe as used
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has concluded that Palmitoyl Proline, as part of 115 amino acid alkyl amides, is safe for use in cosmetic products when formulated to be non-irritating. The European Cosmetics Regulation similarly confirms the suitability of Sodium Palmitoyl Proline, contingent upon adherence to established concentration limits.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Palmitoyl Proline is a valuable multi-functional ingredient, clinically demonstrated to enhance skin elasticity, reduce redness, improve tone, and offer antioxidant protection with a low risk of irritation across all skin types.

Related

Similar Ingredients

Finding similar ingredients…