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PALMITOYL PEA AMINO ACIDS.

Valuable CAS 226993-78-8 / HAIR CONDITIONING, SKIN CONDITIONING

PALMITOYL PEA AMINO ACIDS is a derivative of Palmitoylethanolamide (PEA), an endocannabinoid-like lipid mediator recognized for its significant skin-calming and protective properties. It works efficiently even at low concentrations to soothe sensitive or irritated skin, diminishing the appearance of redness and discomfort. This ingredient also plays a crucial role in supporting the skin's natural barrier function.

Summary

Skin-soothing Anti-inflammatory Antioxidant Skin-calming Barrier support Redness reduction

Science

Mechanism of Action

As a key component, Palmitoylethanolamide (PEA) primarily operates by engaging the nuclear receptor peroxisome proliferator-activated alpha (PPAR-α), which controls gene expression related to inflammatory responses. It also interacts with GPR55 and GPR119 receptors, and indirectly activates cannabinoid receptors CB1 and CB2 through an 'entourage effect' by preventing anandamide degradation. Furthermore, PEA desensitizes TRPV1 channels, contributing to anti-nociceptive effects. Its multifaceted action includes inhibiting mast cell activation, thereby reducing the release of inflammatory mediators such as histamine, prostaglandin D2, and TNF-α. It also reduces the expression of COX-2 and iNOS. These actions collectively translate to powerful skin-soothing, anti-inflammatory benefits, support for the skin's natural defenses against external stressors, and protection of the skin barrier.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Topical application at low concentrations demonstrates high efficacy in calming irritated skin, reducing redness and discomfort, and fortifying the skin barrier.
  2. 02 In an in vitro study, 0.1 mg of Palmitoylethanolamide effectively inhibited the release of histamine, prostaglandin D2, and TNF-α in isolated canine skin mast cells when stimulated by allergens.

Transparency

Dusting Analysis

Not commonly dusted

There is no information to suggest this ingredient is commonly 'dusted' or used at ineffective percentages in formulations.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Palmitoylethanolamide is highly lipophilic, rendering it nearly insoluble in water and poorly soluble in most aqueous solutions. This characteristic can limit its absorption and bioavailability. To enhance its functionality and skin penetration, advanced delivery systems such as micronized, ultra-micronized, or emulsified forms are often employed.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

When applied topically, Palmitoylethanolamide is considered possibly safe for use for up to 28 days. However, there is insufficient reliable data to ascertain its safety for prolonged use, or during pregnancy and breastfeeding. It's important to note that Pea Protein Isolate, while related, is a distinct ingredient that the FDA has determined to be Generally Recognized As Safe (GRAS) for food use.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

PALMITOYL PEA AMINO ACIDS is a valuable ingredient for sensitive and irritated skin, offering significant anti-inflammatory, soothing, and barrier-supporting benefits with broad skin compatibility and a low risk of irritation.

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