Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

PALMITOYL OLIGOPEPTIDE-78.

Valuable / SKIN CONDITIONING

Palmitoyl Oligopeptide-78 is a synthetic lipo-peptide engineered to act as a signaling molecule in the skin. It precisely stimulates keratin production, enhancing epidermal thickness and reinforcing the skin's natural barrier function for improved resilience.

Summary

Skin-restoring Barrier enhancer Skin-identical ingredient Peptide Antioxidant Antimicrobial/antibacterial

Science

Mechanism of Action

This biomimetic lipo-peptide functions by stimulating keratinocytes to produce more keratin, which is crucial for building a robust epidermis. This action leads to increased epidermal thickness and a reduction in transepidermal water loss (TEWL), thereby strengthening the skin's barrier. In combination with Palmitoyl Heptapeptide-27, it further boosts the synthesis of filaggrin and loricrin proteins, essential components for a healthy barrier, natural moisturizing factors (NMF), and optimal skin pH, promoting overall skin homeostasis. Variants also exhibit antioxidant and antibacterial properties, offering protection against environmental stressors.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

Information regarding 'dusting' practices for Palmitoyl Oligopeptide-78 is not available in the provided research data.

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 6.5
0 7 14

Stability

The peptide maintains stability in aqueous formulations, with an optimal pH range of 5.0 to 6.5 recommended for peptide integrity, particularly in hair care applications.

Synergies

  • Palmitoyl Heptapeptide-27 (enhances barrier function proteins, NMF, and pH balance)

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Low

While the Cosmetic Ingredient Review (CIR) Expert Panel has generally deemed 'Palmitoyl Oligopeptides' as a group to be safe, they noted insufficient specific data for individual peptides like Palmitoyl Oligopeptide-78, preventing a dedicated individual safety assessment by CIR, SCCS, or FDA. However, the Environmental Working Group (EWG) Skin Deep database rates the broader 'Palmitoyl Oligopeptide' category as 'LOW' for common concerns including cancer, allergies & immunotoxicity, and developmental and reproductive toxicity.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Palmitoyl Oligopeptide-78 is a valuable signaling peptide, demonstrating potential for enhancing skin barrier function and epidermal thickness, particularly in combination, though more individual skin efficacy data would further clarify its precise standalone impact.

Related

Similar Ingredients

Finding similar ingredients…