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PALMITOYL LYSYL AMINOVALEROYL LYSINE.

Valuable CAS - / SKIN CONDITIONING

This advanced peptide derivative incorporates a palmitoyl group to enhance its bio-availability and penetration into the skin. Functioning as a potent skin conditioning agent, it actively contributes to maintaining optimal skin health and is posited to engage in critical cellular signaling pathways that may improve skin resilience and structure. Its unique amphiphilic properties also offer potential benefits for formulation stability.

Summary

Skin conditioning Collagen synthesis support Anti-aging Enhances skin firmness Improves skin elasticity Emulsifying Stabilizing Cell proliferation enhancement

Science

Mechanism of Action

PALMITOYL LYSYL AMINOVALEROYL LYSINE primarily acts as a skin conditioning agent, diligently supporting the skin's healthy state. As a modified peptide, its palmitoyl moiety is specifically engineered to significantly improve its permeation across biological membranes, allowing for more effective interaction within epidermal and dermal layers. While direct clinical studies for this specific molecule are pending, its peptide structure strongly suggests involvement in cellular communication. Mechanistic understanding, drawn from closely related peptides such as Palmitoyl Tripeptide-1 and Palmitoyl Tripeptide-5, indicates potential to stimulate endogenous collagen production. This stimulation is theorized to occur either by mimicking signals associated with collagen breakdown or by activating key growth factors like TGF-beta, which is indispensable for the synthesis of collagen types I & II and fibronectin, critical components for maintaining skin elasticity and firmness. The lysine component itself further supports skin health by potentially promoting increased cellular proliferation.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

No definitive optimal pH range for the stability of PALMITOYL LYSYL AMINOVALEROYL LYSINE has been precisely identified. However, it is important to note that the ε-amino group within its lysine component maintains a polar, protonated state at physiological pH, typically around 7.4. Furthermore, observations from structurally related poly-L-lysine compounds indicate that their conformational stability can be influenced by pH variations within the range of 4 to 8, suggesting that formulation pH could play a role in the performance characteristics of this ingredient.

Safety

Safety Profile

CIR Status
Safe as used
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has determined that PALMITOYL LYSYL AMINOVALEROYL LYSINE, an amino acid alkyl amide, is safe for use in cosmetics under current practices and concentrations, provided the final formulation is non-irritating. This safety assessment is predicated on the low concern regarding systemic exposure to its metabolic constituents, which are common amino acids and fatty acids. While a specific maximum concentration for PALMITOYL LYSYL AMINOVALEROYL LYSINE was not detailed, similar amino acid alkyl amides have been deemed safe at concentrations up to 45% when properly formulated. L-amino acids are generally recognized as safe (GRAS) by the FDA for direct food additive use.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

PALMITOYL LYSYL AMINOVALEROYL LYSINE is a valuable peptide derivative with strong theoretical potential to condition skin and support collagen production, enhancing firmness and reducing visible signs of aging, especially when precisely formulated.

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