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Moumoujus

PALMITOYL HISTIDYL D-PHENYLALANYL ARGININE.

Valuable / SKIN CONDITIONING

Palmitoyl Histidyl D-Phenylalanyl Arginine, a synthetic peptide also known as Palmitoyl Tripeptide-8, is designed to reduce skin inflammation and enhance overall skin health. It actively calms reactivity and alleviates symptoms like redness and swelling, while also contributing to improved skin texture and elasticity.

Summary

Anti-inflammatory Skin-soothing Improves skin elasticity Enhances skin texture Reduces redness Reduces swelling Skin conditioning

Science

Mechanism of Action

This peptide operates by modulating inflammatory responses through its interaction with the melanocortin 1 receptor (MC1-R). By inhibiting the binding of α-melanocyte-stimulating hormone (α-MSH) to MC1-R, it effectively reduces the release of key inflammatory cytokines, such as IL-8 induced by UVB radiation and IL-1α. This action not only diminishes redness and swelling but also mitigates neurogenic edema and adverse effects associated with substance P release, providing significant soothing benefits to the skin.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

The peptide's stability across various formulations is enhanced by its palmitic acid modification, ensuring its suitability for diverse cosmetic products.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Unknown

While generally considered safe for cosmetic use according to industry guidelines, detailed safety profile data, including specific CIR or SCCS reviews, are not explicitly available in public research. SpecialChem also reports 'No data available' for its safety profile.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Palmitoyl Histidyl D-Phenylalanyl Arginine offers valuable anti-inflammatory and skin-soothing benefits, alongside improvements in skin elasticity and texture, although comprehensive independent safety and optimal concentration data are currently limited.

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