Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

PALMITOYL HEPTAPEPTIDE-18.

Valuable / SKIN CONDITIONING

Palmitoyl Heptapeptide-18 is an advanced biomimetic peptide engineered to address dynamic wrinkles. It functions as a smart ligand, precisely targeting the neural mechanisms underlying muscle micro-contractions, offering a non-invasive approach to visibly smoother skin.

Summary

anti-aging moisturizing muscle relaxant (Botox-like effect)

Science

Mechanism of Action

This peptide operates by acting as a smart ligand that specifically engages neuronal cells responsible for deeper skin muscle micro-contractions. Its primary action involves repressing calcium influx into these neurons, which in turn inhibits the release of acetylcholine into the synaptic space. This interruption of neurotransmission results in a localized relaxing effect, functionally mimicking a 'Botox-like' outcome without the need for injections.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

0.001%

Key findings

  1. 01 A clinical study demonstrated that when Palmitoyl Heptapeptide-18 was utilized at a concentration of 0.001% in conjunction with Palmitoyl Hexapeptide-52, this peptide blend led to a significant reduction in the appearance of deep wrinkles and fine lines, ranging from 20% to 27%, over a 28-day treatment period.

Transparency

Dusting Analysis

Not commonly dusted

The documented effective concentration of 0.001% for Palmitoyl Heptapeptide-18 is specific to its use within a synergistic peptide complex. Given its targeted mechanism and specified use, it is positioned as an active ingredient rather than a component commonly added below effective levels for marketing purposes.

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

The molecular design of Palmitoyl Heptapeptide-18, featuring a lipid modification, inherently boosts its stability, enhances its dispersibility, and improves its compatibility within complex multi-phase systems. This structural enhancement facilitates its integration into advanced skincare formulations and targeted peptide delivery systems. Optimal storage conditions involve a well-ventilated, dry environment at 2-8 °C, with long-term preservation requiring temperatures below -20 °C, and strict avoidance of direct sunlight.

Synergies

  • Palmitoyl Hexapeptide-52

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

While the Cosmetic Ingredient Review (CIR) Expert Panel has assessed certain other palmitoyl oligopeptides, Palmitoyl Heptapeptide-18 itself has not undergone a dedicated safety review by the CIR based on the available literature. However, it is generally considered to have a low irritancy potential.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Palmitoyl Heptapeptide-18 is a valuable precision active that targets the neurological origins of dynamic wrinkles, offering a sophisticated 'Botox-like' effect for visibly smoother and younger-looking skin, particularly when used in synergistic formulations.

Related

Similar Ingredients

Finding similar ingredients…