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Moumoujus

PALMITOYL GRAPE SEED EXTRACT.

Valuable CAS 226994-27-0 / SKIN CONDITIONING

Palmitoyl Grape Seed Extract is a sophisticated derivative combining the potent antioxidant benefits of grape seed extract with palmitic acid, enhancing its skin compatibility and efficacy. It provides comprehensive protection against environmental stressors, fortifies the skin barrier, and promotes a brighter, more youthful complexion through multiple pathways.

Summary

Antioxidant Anti-inflammatory Skin Barrier Support Hydrating Cell Turnover Promotion Brightening Anti-aging UVB Protection Collagen Support Elastin Support Skin Conditioning

Science

Mechanism of Action

This ingredient operates via a multifaceted mechanism to improve skin health. The grape seed extract component, rich in proanthocyanidins, acts as a powerful antioxidant, effectively neutralizing free radicals and mitigating oxidative stress. It exhibits anti-inflammatory properties by reducing inflammatory cytokine levels, thereby calming the skin and fostering a more even tone. The palmitic acid moiety contributes to strengthening the skin's natural barrier by integrating into the stratum corneum's lipid structure, which significantly enhances moisture retention. Palmitoyl Grape Seed Extract also stimulates skin cell turnover, leading to smoother, more radiant skin, and actively promotes the production of vital structural proteins like collagens, elastin, and filaggrin, along with dermal-epidermal junction (DEJ) markers. Furthermore, it protects against UVB-induced inflammation and DNA damage, while contributing to skin brightening by reducing melanin synthesis and inhibiting tyrosinase activity.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

The palmitoyl modification, derived from palmitic acid, enhances the ingredient's lipid compatibility, contributing to its oil solubility. While specific optimal pH data for Palmitoyl Grape Seed Extract is not available, studies on generic grape seed extract suggest that alkaline solutions (e.g., pH 11.92) maintain better stability for certain biomodifying actions over at least 14 days, compared to more acidic solutions (e.g., pH 4.42).

Safety

Safety Profile

CIR Status
Safe as used
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has affirmed the safety of Vitis vinifera (grape)-derived ingredients, including Grape Seed Extract, at current cosmetic uses and concentrations. Irritation and sensitization tests consistently indicate a low potential for dermal irritation or sensitization. SkinSAFE rates Palmitoyl Grape Seed Extract as 'SkinSAFE 100 Free', 'Irritant Free', and 'Dye Free'. The EWG Skin Deep database also assigns a 'LOW' concern for cancer, allergies & immunotoxicity, and developmental and reproductive toxicity.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Palmitoyl Grape Seed Extract is a valuable, multifunctional ingredient that provides robust antioxidant protection, strengthens the skin barrier, and contributes to a brighter, more even, and youthful complexion, suitable for all skin types.

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