Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

PALMITOYL GLUTAMIC ACID.

Valuable CAS 38079-66-2 / SKIN CONDITIONING

Palmitoyl Glutamic Acid is a synthetic derivative of glutamic acid, engineered with a palmitoyl group to enhance its lipid solubility. This modification allows it to serve as an effective carrier for other active ingredients, facilitating deeper penetration into the skin. It also functions as a skin conditioning agent and formulation stabilizer.

Summary

Skin conditioning Emulsification Active ingredient delivery Anti-aging support Moisturizing

Science

Mechanism of Action

This ingredient's palmitoyl modification significantly increases its lipophilicity, enabling it to transport peptides, antioxidants, and other active compounds more efficiently into the epidermis and dermis. It can mimic or be a component of palmitoyl-peptides, activating cellular pathways to stimulate collagen and elastin synthesis, thereby enhancing skin density and elasticity and diminishing the appearance of fine lines and wrinkles. Additionally, it offers direct moisturizing and protective benefits as a skin-conditioning agent, and its surfactant properties contribute to emulsion stability in formulations.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

No specific data on typical dusting concentrations or red flag percentages was identified for Palmitoyl Glutamic Acid. Its role as a carrier implies it may be present alongside other actives.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Palmitoyl Glutamic Acid's lipophilic nature means it is primarily soluble in oil-based systems, forming clear solutions. While not inherently water-soluble, it can be suspended in aqueous mediums with the aid of heat and/or sonication. Its surfactant properties are valuable for improving emulsion formation and overall formulation stability. Stock solutions are recommended for storage at -80°C for up to 6 months, or -20°C for 1 month.

Safety

Safety Profile

CIR Status
Safe as used
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel deemed Palmitoyl Glutamic Acid, within a group of 115 amino acid alkyl amides, as safe for use in cosmetics under current practices and concentrations, provided it is formulated to be non-irritating. Human Repeat Insult Patch Test (HRIPT) studies found related amino acid ingredients at concentrations up to 2.784% to be non-irritating or sensitizing. A specific maximum concentration for Palmitoyl Glutamic Acid alone was not specified.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Palmitoyl Glutamic Acid is a valuable multifunctional ingredient, enhancing the delivery of actives and supporting skin regeneration, while also providing conditioning and formulation stability.

Related

Similar Ingredients

Finding similar ingredients…