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PALMITOYL DIPEPTIDE-7.

Valuable CAS - / SKIN CONDITIONING

Palmitoyl Dipeptide-7 is a sophisticated signaling peptide engineered to enhance skin's structural integrity and antioxidant defenses. It directly communicates with dermal fibroblasts to stimulate the synthesis of crucial proteins like collagen and laminin, while also activating the NRF2 pathway for boosted cellular protection. Its lipophilic nature ensures optimized skin penetration and prolonged activity.

skin conditioning antioxidant anti-aging improves elasticity promotes collagen synthesis strengthens skin barrier

Science

This advanced signaling peptide precisely targets dermal fibroblasts, orchestrating an upregulation of vital skin functions. It actively promotes the synthesis and secretion of foundational structural proteins, including Collagen Type I and IV, Fibronectin, and Laminin, thereby reinforcing the skin's architecture from within. Palmitoyl Dipeptide-7 also enhances the differentiation and functional capacity of fibroblasts within the dermis and at the dermal-epidermal junction, critical for maintaining a robust skin infrastructure. Genetic analysis indicates its influence on genes associated with wound healing, tissue repair, and overall skin recovery. Furthermore, it activates the NRF2 signaling pathway, a master regulator of antioxidant defense, which consequently boosts the production of intrinsic antioxidant enzymes such as superoxide dismutase, glutathione peroxidase, and glutathione reductase. The attached palmitoyl fatty acid chain is integral to its design, significantly increasing its lipophilicity for superior skin penetration and secure anchoring within the skin's lipid layers, ensuring sustained biological activity.


Research

Low confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted

The Formula

Solubility
Both
Optimal pH 4 – 7
0 7 14

Stability

This peptide exhibits stability across a pH range of 4.0 to 7.0. For optimal preservation of its efficacy and stability, it should be integrated into the water phase of formulations at temperatures not exceeding 45°C, typically during the cooling phase of emulsion preparation.

Conflicts

  • strong acids
  • strong oxidants

Safety

CIR Status
Insufficient data
Sensitization risk Low

Palmitoyl Dipeptide-7 was listed in the FDA's Voluntary Cosmetic Registration Program (VCRP) in 2012. While broader 'palmitoyl oligopeptides' have been reviewed by CIR, a specific safety assessment exclusively for Palmitoyl Dipeptide-7 with a definitive conclusion is not readily available in the provided research. However, it is generally regarded as safe for topical cosmetic application and adheres to relevant cosmetic regulations.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Valuable

A mechanistically robust peptide that stimulates structural protein synthesis and enhances antioxidant defenses, making it a valuable asset for comprehensive skin rejuvenation and barrier support.


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