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PALMITOYL DIPEPTIDE-5 DIAMINOHYDROXYBUTYRATE.

Valuable CAS - / SKIN CONDITIONING

A synthetic signal peptide designed to bolster the skin's structural integrity, Palmitoyl Dipeptide-5 Diaminohydroxybutyrate promotes a visibly smoother and firmer complexion by supporting critical proteins at the dermal-epidermal junction.

Skin-conditioning

Science

This bioactive synthetic signal peptide operates by targeting the dermal-epidermal junction (DEJ), a crucial interface between the dermis and epidermis. It supports the synthesis and organization of specific collagens and proteins essential for the DEJ's strength and function. This signaling action activates the skin's endogenous repair mechanisms, which in turn helps to mitigate the appearance of lines and wrinkles, enhance skin elasticity, and improve overall firmness and suppleness.


Research

Medium confidence
Effective range 1–3%
Optimal

N/A


Transparency

Not commonly dusted

The Formula

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

For research-grade powder, it is recommended to store away from moisture at -20°C for up to 3 years, or at -80°C for 1 year when dissolved in a solvent.


Safety

CIR Status
Not reviewed
Sensitization risk Low

EWG Skin Deep assesses this ingredient with a 'LOW' hazard rating across categories including Cancer, Allergies & Immunotoxicity, and Developmental and Reproductive Toxicity, and it is not present on their Restricted or Unacceptable Lists. Paula's Choice considers it a 'Best' ingredient, signifying its proven efficacy and suitability for most skin types. Specific safety data or maximum concentration limits from CIR, SCCS, or FDA are currently unavailable.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Valuable

Palmitoyl Dipeptide-5 Diaminohydroxybutyrate is a valuable peptide for anti-aging formulations, effectively targeting skin firmness, elasticity, and texture by supporting the dermal-epidermal junction across all skin types with a low risk of irritation.


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