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PALMITOYL DIPEPTIDE-28 D-SERINE DIPEPTIDE-7 PALMITAMIDE.

Valuable / SKIN CONDITIONING

This sophisticated peptide complex is engineered to revitalize the skin, primarily through the actions of its Palmitoyl Dipeptide-7 component. It functions as a potent cellular communicator, stimulating the synthesis of crucial extracellular matrix components while also enhancing the skin's inherent antioxidant defenses for improved resilience and vitality.

Summary

Anti-aging Collagen_Stimulation Elastin_Production Hyaluronic_Acid_Enhancement Antioxidant Skin_Firming Skin_Elasticity_Improvement Wrinkle_Reduction Barrier_Repair Moisturizing

Science

Mechanism of Action

Drawing from research on Palmitoyl Dipeptide-7, this signal peptide directly engages dermal fibroblasts to upregulate essential functions. It robustly stimulates the synthesis of extracellular matrix (ECM) proteins, specifically targeting Collagen Type I and IV, Fibronectin, and Laminin. Additionally, it activates the NRF2 signaling pathway, promoting the generation of antioxidant enzymes to effectively counteract oxidative stress. The peptide also boosts the natural production of elastin and hyaluronic acid, contributing to enhanced skin firmness, elasticity, and a reduction in the appearance of wrinkles and fine lines.

Research

Clinical Evidence

Medium confidence
Effective range 0.05–0.2%
Optimal

N/A

Key findings

  1. 01 Recommended usage levels for Palmitoyl Dipeptide-7 between 0.05% and 0.2% in final formulations have demonstrated efficacy in promoting collagen synthesis, enhancing skin elasticity, and improving firmness.

Transparency

Dusting Analysis

Not commonly dusted

Insufficient data available to determine dusting properties or common dusting practices for this specific ingredient.

The Formula

Formulation

Solubility
Both
Optimal pH 4 – 7
0 7 14

Stability

For maintaining optimal stability and efficacy, Palmitoyl Dipeptide-7 should be incorporated into the water phase during emulsion preparation. This addition should occur at temperatures below 45°C, specifically after the cooling phase.

Safety

Safety Profile

CIR Status
Safe as used
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has concluded that Palmitoyl Dipeptide-7, along with other palmitoyl oligopeptides, is safe for use in cosmetic formulations under current practices and concentrations. It is globally recognized as safe and compliant, with no widely reported adverse side effects, allergic reactions, or increased sensitivity.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

This complex peptide, operating through its Palmitoyl Dipeptide-7 component, is a valuable ingredient for comprehensive anti-aging and skin regeneration, significantly enhancing firmness, elasticity, and antioxidant defense mechanisms.

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