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Moumoujus

PALMITOYL DIPEPTIDE-18.

Insufficient Data / VISCOSITY CONTROLLING

Palmitoyl Dipeptide-18 is a sophisticated lipophilic peptide engineered to bolster the skin's natural barrier, enhance moisture retention, and stimulate the synthesis of crucial structural proteins. It actively works to diminish the appearance of wrinkles and expression lines, while also imparting soothing and repairing benefits to the skin.

Summary

Skin Barrier Enhancement Moisture Retention Collagen Synthesis Booster Elasticity Improvement Wrinkle Reduction Expression Line Relaxation Soothing Anti-inflammatory Skin Repair Fibroblast Activation Elastin Production Hyaluronic Acid Production

Science

Mechanism of Action

This peptide operates through a multi-pronged approach, primarily by reinforcing the skin barrier and optimizing moisture levels. It significantly promotes the synthesis of matrix proteins, collagen, elastin, hyaluronic acid, glycosaminoglycans, and fibronectin, which are essential for maintaining skin firmness and elasticity. By activating fibroblasts and regulating water metabolism, Palmitoyl Dipeptide-18 supports overall skin vitality and health. Additionally, it contributes to a soothing and repairing effect by reducing inflammation and facilitating the repair of damaged skin, and is believed to reduce the release of catecholamines to relax facial muscles, thereby minimizing expression lines.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Palmitoyl Dipeptide-18 should be stored in a cool, dry environment, ideally between 2-8°C, and protected from light. For long-term preservation, temperatures of -20°C to -15°C are recommended, maintaining an airtight package when not in use. The palmitoylation of the peptide significantly improves its inherent stability and enhances skin permeability due to increased lipophilicity.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) currently has Palmitoyl Dipeptide-18 under 'monograph development in progress,' indicating that a definitive safety assessment and maximum concentration for cosmetic use are not yet established. However, acute oral toxicity studies in rats have shown commercialized products containing 0.01% (100 ppm) of this ingredient to be non-toxic. Supplier information further assures that the ingredient is free from heavy metals and is non-irritating to both skin and eyes.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Insufficient Data

Palmitoyl Dipeptide-18 exhibits promising multi-functional benefits for addressing skin aging and repair; however, its full clinical efficacy and long-term safety profile await comprehensive regulatory assessment by the CIR.

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References

Sources